Transanal total mesorectal excision (taTME) for rectal cancer: a systematic review and meta-analysis of oncological and perioperative outcomes compared with laparoscopic total mesorectal excision

Table 3 Subgroup analysis based on total taTME

Outcomes	No. of patients		No. of studies	OR/WMD	95%CI	Heterogeneity		P value
Outcomes	taTME	laTME		Low high		I²	P value	P value
Oncological outcomes
Mactoscopic quality of mesorectum	119	119	4	2.03	0.99 4.16	11%	0.34	0.05
Harvested lymph nodes	169	219	5	−0.45	−1.98 1.08	0%	0.93	0.56
Circumferential resection margin	161	205	5	0.94	0.57 1.30	20%	0.29	<0.01^*
Positive circumferential resectionmargin	119	119	4	0.31	0.08 1.18	0%	0.90	0.09
Distal resection margin	161	205	5	5.48	−0.17 11.13	73%	<0.01	0.06
Positive distal resection margin	83	66	2	5.98	0.71 50.5	0%	0.92	0.10
Perioperative outcomes
Operative time	144	194	4	−23.29	−45.60 -0.98	72%	0.01	0.04^*
Conversion	144	194	4	0.31	0.08 1.18	0%	0.90	0.09
Hospital stay	144	194	4	−1.62	−3.62 0.38	74%	0.01	0.11
Intraoperative complications	144	194	4	0.94	0.30 3.01	0%	0.60	0.92
Postoperative complications	144	194	4	0.59	0.35 0.97	45%	0.14	0.04^*
Anastomotic leakage	144	194	4	0.65	0.30 1.42	0%	0.66	0.28
Ileus	144	194	4	1.37	0.45 4.13	0%	0.49	0.58
Acute urinary retention	144	194	4	0.45	0.18 1.10	0%	0.81	0.08
Mobilization of splenic flexure	112	162	3	2.34	0.99 5.54	54%	0.12	0.05
Readmission	144	194	4	0.52	0.24 1.10	0%	0.57	0.09

taTME transanal total mesorectal excision, laTME laparoscopic total mesorectal excision, OR odds ratios, WMD weighted mean difference, CI confidence interval; *P vaule with statistical significance

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