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Fig. 5 | BMC Cancer

Fig. 5

From: Epigenetic silencing of serine protease HTRA1 drives polyploidy

Fig. 5

Increased polyploidy in Htra1 −/− MEFs and SW480shHTRA1 cells. a Chromosome numbers of Htra1 −/− and Htra1 +/+ MEFs. 50 mitotic cells were analysed by standard karyotyping. The normal set of chromosomes is 40. Shown is the distribution of chromosome numbers (left panel) as well as the mean number (right panel, two-tailed Mann–Whitney U test, p-value <0.01). b 50 mitotic SW480 cells were analysed by standard karyotyping. The normal set of chromosomes is 56–58. (Par, untransfected SW480; shS8 or D3, SW480 with HTRA1 downregulated via two independent shRNAs; EV ctrl., corresponding to control carrying nonsense shRNA). The distribution of chromosome numbers (left panel) and the mean number (right panel, two-tailed Mann–Whitney U test, p-values: EV ctrl. = 0,7790, shD3 < 0.0001, shS8 < 0.0001) are shown

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