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Fig. 2 | BMC Cancer

Fig. 2

From: Metformin treatment modulates the tumour-induced wasting effects in muscle protein metabolism minimising the cachexia in tumour-bearing rats

Fig. 2

Muscle proteins are mainly degraded by proteasome pathway in Walker 256 tumour-bearing rats and metformin modulates this via. Enzyme activity of three different protein degradation pathways was analysed: (a) calcium-dependent pathway, (b and c) lysosomal pathway and (d) ubiquitin-proteasome pathway. Metformin modulates chymotrypsin-like activity in Walker 256 tumour-bearing rats bring the value close to C. Legend: C, control rats; W, Walker 256 tumour-bearing rats; M, metformin-treated rats (33 mg/Kg); WM, Walker 256 tumour-bearing rats treated with metformin (33 mg/Kg). Number of animals per group = 8. Columns represent mean ± SD. *p < 0.05 vs C; #p < 0.05 vs W

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BMC Cancer

ISSN: 1471-2407

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