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Table 2 Previous studies of PIK3CA mutations in gastric cancer

From: Prognostic and clinical impact of PIK3CA mutation in gastric cancer: pyrosequencing technology and literature review

Sample number Mutation rate Exons evaluated Method References
163 5.5 % 9 and 20 Direct sequencing [36]
263 16 % 9 and 20 Direct sequencing [27]
12 25 % 18 and 20 Sanger method [6]
47 11 % 9 and 20 ABI prism 377 automated sequencer [37]
94 4.3 % 9 and 20 Direct sequencing [38]
185 6.5 % 9, 18 and 20 PCR – SSCP [39]
34 6.0 % 9 and 20 High-Resolution [40]
Melt Analysis
295 24 % All exon Mut Sig CV [41]
140 4.0 % 9 and 20 ABI PRISM 3100 [42]
Genetic Analyzer
231 8.7 % 1, 9 and 20 Pyrosequencing [26]
104 7.7 % 9 and 20 Direct sequencing [28]