Sample number | Mutation rate | Exons evaluated | Method | References |
---|---|---|---|---|
163 | 5.5Â % | 9 and 20 | Direct sequencing | [36] |
263 | 16Â % | 9 and 20 | Direct sequencing | [27] |
12 | 25Â % | 18 and 20 | Sanger method | [6] |
47 | 11Â % | 9 and 20 | ABI prism 377 automated sequencer | [37] |
94 | 4.3Â % | 9 and 20 | Direct sequencing | [38] |
185 | 6.5 % | 9, 18 and 20 | PCR – SSCP | [39] |
34 | 6.0Â % | 9 and 20 | High-Resolution | [40] |
Melt Analysis | ||||
295 | 24Â % | All exon | Mut Sig CV | [41] |
140 | 4.0Â % | 9 and 20 | ABI PRISM 3100 | [42] |
Genetic Analyzer | ||||
231 | 8.7Â % | 1, 9 and 20 | Pyrosequencing | [26] |
104 | 7.7Â % | 9 and 20 | Direct sequencing | [28] |