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Table 2 Previous studies of PIK3CA mutations in gastric cancer

From: Prognostic and clinical impact of PIK3CA mutation in gastric cancer: pyrosequencing technology and literature review

Sample number

Mutation rate

Exons evaluated

Method

References

163

5.5 %

9 and 20

Direct sequencing

[36]

263

16 %

9 and 20

Direct sequencing

[27]

12

25 %

18 and 20

Sanger method

[6]

47

11 %

9 and 20

ABI prism 377 automated sequencer

[37]

94

4.3 %

9 and 20

Direct sequencing

[38]

185

6.5 %

9, 18 and 20

PCR – SSCP

[39]

34

6.0 %

9 and 20

High-Resolution

[40]

Melt Analysis

295

24 %

All exon

Mut Sig CV

[41]

140

4.0 %

9 and 20

ABI PRISM 3100

[42]

Genetic Analyzer

231

8.7 %

1, 9 and 20

Pyrosequencing

[26]

104

7.7 %

9 and 20

Direct sequencing

[28]