Table 1 PIK3CA mutational status and clinical features in gastric cancers
Features | Total | PIK3CA mutation | p value | |
|---|---|---|---|---|
Mutant | Wild-Type | |||
n = 208 | n = 25 (12 %) | n = 183 (88 %) | ||
Age (year) | Â | Â | Â | 0.30 |
 Mean ± SE | 208 | 67.4 ± 2.1 | 69.8 ± 0.8 |  |
Sex | Â | Â | Â | 0.41 |
 Male | 148 | 16 (11) | 132 (89) |  |
 Female | 60 | 9 (15) | 51 (85) |  |
Location | Â | Â | Â | 0.22 |
 Upper | 75 | 13 (17) | 62 (83) |  |
 Middle | 65 | 6 (9) | 59 (91) |  |
 Lower | 68 | 6 (9) | 62 (91) |  |
Tumor depth | Â | Â | Â | 0.09 |
 T1 | 105 | 18 (17) | 87 (83) |  |
 T2 | 29 | 2 (6) | 29 (94) |  |
 T3 | 42 | 2 (5) | 42 (95) |  |
 T4 | 25 | 3 (11) | 25 (89) |  |
Lymph node involvement | Â | Â | Â | 0.73 |
 Absent | 135 | 17 (13) | 118 (87) |  |
 Present | 73 | 8 (11) | 65 (83) |  |
Stage | Â | Â | Â | 0.78 |
 I | 123 | 17 (14) | 106 (86) |  |
 II | 40 | 4 (10) | 36 (90) |  |
 III | 26 | 2 (8) | 24 (92) |  |
 IV | 19 | 2 (11) | 17 (89) |  |
Lauren classification | Â | Â | Â | 0.79 |
 Intestinal | 138 | 16 (12) | 122 (88) |  |
 Diffuse | 70 | 9 (13) | 61 (87) |  |
Venous invasion | Â | Â | Â | 0.05 |
 Absent | 111 | 18 (16) | 93 (84) |  |
 Present | 95 | 7 (7) | 88 (93) |  |
Lymphatic invasion | Â | Â | Â | 0.40 |
 Absent | 117 | 16 (14) | 101 (86) |  |
 Present | 91 | 9 (10) | 82 (90) |  |
LINE-1 methylation level (%) | Â | Â | Â | 0.19 |
 Mean ± SE | 208 | 74.9 ± 2.6 | 71.2 ± 1.0 |  |