Table 3 Univariate analyses of factors independently prognostic of overall survival in the 307 patients with hepatocellular carcinoma

Sex

0.39

0.28

0.156

1.48

0.86–2.54

Age

−0.09

0.08

0.293

0.92

0.78–1.08

ECOG PS

0.74

0.10

0.000

2.10

1.74–2.54

Tumor size

0.15

0.02

0.000

1.16

1.12–1.21

Number of lesions

0.58

0.10

0.000

1.78

1.47–2.17

Lobar involvement

1.16

0.20

0.000

3.20

2.18–4.70

Tumor formation

0.70

0.11

0.000

2.01

1.63–2.49

Ascites

0.44

0.10

0.000

1.55

1.27–1.89

Total bilirubin

0.68

0.14

0.000

1.98

1.51–2.60

Albumin

−0.10

0.02

0.000

0.91

0.88–0.94

Child-Pugh Grade

0.86

0.16

0.000

2.37

1.72–3.25

alpha-fetoprotein

0.72

0.18

0.000

2.05

1.43–2.94

hepatitis B virus

−0.37

0.21

0.081

0.69

0.46–1.05

hepatitis C virus

−0.55

0.59

0.347

0.58

0.18–1.82

Alcoholism

0.53

0.59

0.366

1.70

0.54–5.36

Other

0.42

0.23

0.066

1.53

0.97–2.39

Lymph node metastasis

0.81

0.21

0.000

2.26

1.48–3.43

Distant metastasis

1.37

0.22

0.000

3.93

2.56–6.05

Tumor thromboses

1.31

0.20

0.000

3.71

2.50–5.50

Portal hypertension

0.30

0.22

0.173

1.35

0.88–2.09

Cirrhosis

−0.80

0.18

0.000

0.45

0.31–0.64

Vascular/organ invasion

 Portal/hepatic vein

1.31

0.21

0.000

3.72

2.47–5.60

 Others

0.79

0.33

0.015

2.21

1.17–4.18