Table 1 Baseline demographic and clinical characteristics of the 307 patients with hepatocellular carcinoma (Additional files 1 and 2)

Age, years

 Mean ± SD

55.43 ± 10.69

 Range

11–84

Sex, %

 Male

252 (82.1)

 Female

55 (17.9)

ECOG PS, %

 0

100 (32.6)

 1

146 (47.6)

 2

44 (14.3)

 3

16 (5.2)

 4

1 (0.3)

Etiology, %

 HBV

239 (77.8)

 HCV

7 (2.3)

 HBV + HCV

2 (0.7)

 Alcoholism

5 (1.6)

 Other

54 (17.6)

Child-Pugh Grade, %

 A

239 (77.9)

 B

56 (18.2)

 C

12 (3.9)

Child-Pugh Score, %

 5

176 (57.4)

 6

63 (20.5)

 7

36 (11.7)

 8

9 (2.9)

 9

11 (3.6)

 10

9 (2.9)

 11

3 (1.0)

Hepatic encephalopathy, %

 No

307 (100.0)

 Yes

0 (0)

Ascites, %

 No

219 (71.4)

 Little

56 (18.2)

 Middle

24 (7.8)

 Large

8 (2.6)

Portal hypertension, %

 No

245 (79.8)

 Yes

62 (20.2)

Cirrhosis, %

 No

97 (31.6)

 Yes

210 (68.4)

Laboratory values, mean ± SD

 Total bilirubin (μmol/l)

24.55 ± 50.93

 Albumin (g/l)

38.53 ± 5.78

 Prothrombin time (sec)

0.19 ± 0.80

 AFP (ng/ml), %

   < 400

211 (68.7)

   ≥ 400

96 (31.3)

Tumor characteristics

 Tumor size (mean ± SD, cm)

6.18 ± 4.04

 Number of lesions, %

  1

200 (65.2)

  2–3

29 (9.4)

   ≥ 4

78 (25.4)

 Lobar involvement, %

  Unilobar

164 (53.4)

   ≥ bilobar

143 (46.6)

 Tumor morphology, %

  Uninodular

147 (47.9)

  Multinodular

77 (25.1)

  Massive, diffuse

83 (27.0)

 Vascular and/or organ invasion, %

  No

235 (76.6)

  Portal/hepatic vein

52 (16.9)

  Other vascular

9 (2.9)

  Organ invasion

11 (3.6)

 N, %

  No

252 (82.1)

  Yes

55 (17.9)

 M, %

  No

278 (90.6)

  Yes

29 (9.4)

 Tumor thrombosis, %

  None

247 (80.4)

  Portal stem vein

26 (8.5)

  Inferior vena cava

6 (1.9)

  Hepatic vein branches

2 (0.7)

  Portal vein branches

16 (5.2)

  Vessel

3 (1.0)

  Hepatic duct

2 (0.7)

  Inferior vena cava branches and Portal vein branches and/or Hepatic vein branches

5 (1.6)

Current outcomes, %

 Dead

120 (39.1)

 Alive

187 (60.9)

OS, mean ± SD, months

12.08 ± 11.87