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Fig. 5 | BMC Cancer

Fig. 5

From: GSK-3 directly regulates phospho-4EBP1 in renal cell carcinoma cell-line: an intrinsic subcellular mechanism for resistance to mTORC1 inhibition

Fig. 5

Combination effects of AR-A014418 and rapamycin in ACHN cells. a ACHN cells were treated with AR-A014418 and rapamycin as single agents or their combination at different concentration at a constant dilution ratio of 25,000 : 1. Cell viability was assessed using MTS assay after 72 h incubation. Data are the mean ± SD in each bar-plot from four replicates of ACHN cells at each concentration. b Effects of the drug combination was demonstrated on a Fa-CI plot generated using CompuSyn. Combination index (CI) determines the type of drug interaction as follows: additive, synergistic, or antagonistic if CI is 1, < 1 or > 1, respectively [26]. The combination effects varied from additivity to antagonism according to the increase in drug concentration

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