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Table 2 Univariable analysis of overall survival in 1435 patients according to clinicopathological variables

From: Prognostic and predictive significance of tumor length in patients with esophageal squamous cell carcinoma undergoing radical resection

Variable HR 95 % CI P value (C-index) (%)
Age 1.007 0.998–1.015 0.118 52.2
Sex     51.6
 Male (reference) 1    
 Female 0.766 0.608–0.966 0.025  
Tumor location     53.2
 Upper (reference) 1    
 Middle 1.318 0.758–2.292 0.328  
 Lower 1.534 0.882–2.666 0.129  
Differentiation     55.4
 G1 (reference) 1    
 G2 2.094 1.622–2.703 <0.001  
 G3 1.442 1.154–1.802 <0.001  
T stage     60.5
 T1 (reference) 1    
 T2 2.253 1.572–3.230 <0.001  
 T3 3.499 2.545–4.809 <0.001  
 T4 5.593 3.835–8.156 <0.001  
N stage     67.1
 N0 (reference) 1    
 N1 2.001 1.661–2.409 <0.001  
 N2 3.640 3.007–4.406 <0.001  
 N3 6.180 4.882–7.823 <0.001  
Vascular invasion     51.5
 No (reference) 1    
 Yes 1.224 1.001–1.482 0.038  
Perineural involvement     53.8
 No (reference) 1    
 Yes 1.595 1.345–1.891 <0.001  
Number of resected lymph nodes 1.002 0.995–1.008 0.577 50.3
Tumor length     56.1
  ≤ 4.0 cm (reference) 1    
  > 4.0 cm 1.582 1.368–1.830 <0.001  
Tumor length* 1.121 1.088–1.155 <0.001 58.1
  1. *tumor length treated as a continuous variable