Fig. 3
From: Bone alkaline phosphatase as a surrogate marker of bone metastasis in gastric cancer patients
a A 47-year-old female patient with no known bone metastasis at baseline subsequently developed multiple bone metastases at spine and sacrum, rib cage, left scapula, and left ileum. Serum bone ALP levels increased from 19.1 μg/L to 43.0 μg/L. b A 64-year-old male patient initially diagnosed with multiple bone metastases showed favorable response to chemotherapy. The bone metastatic lesions showed a decrease in intensity on bone scintigraphy and bone ALP level was decreased after 3 months of chemotherapy