Long-term survival and BRCA status in male breast cancer: a retrospective single-center analysis

BMC Cancer

Table 2 Characteristics of patients with known BRCA status

Characteristics	BRCA-negative	BRCA1-positive	BRCA2-positive					BRCA UVS
	n = 10	n = 1	Patient 1	Patient 2	Patient 3	Patient 4	Patient 5	n = 1
Age at diagnosis	61.0 [53.8–67.3]	30–40	60–70	70–80	70–80	60–70	70–80	70–80
BMI	26.2 [23.6–32.0]	22.8	24.5	33.6	27.0	23.2	31.4	25.8
Family history	50 %	Yes	No	Yes	No	No	Yes	No
Smoke	0 %	No	Yes	No	Yes	No	No	No
Alcohol intake	10 %	No	Yes	No	No	No	Yes	No
Obesity	20 %	No	No	Yes	No	No	Yes	No
Side	Left (70 %); Right (30 %)	Right	Right	Right	Left	Both	Left	Left
Stage	I (20 %); II (70 %); III (10 %)	II	I	III	III	Unknown	I	I
Histotype	Ductal (100 %)	Ductal	Ductal	Ductal	Ductal	Ductal	Ductal	Ductal
HR status	ER+/PgR+ 9	ER+/PgR	ER+/PgR	ER+/PgR	ER+/PgR	ER+/PgR	ER+/PgR	ER+/PgR
HR status	Unknown 1	+	+	+	+	+	+	+
Node status, positive	50 %	Yes	No	Yes	Yes	No	No	No
HER-2 positive	10 % Unknown (10 %)	No	No	No	Yes	No	No	No
Ki-67 high-level (cutoff 20 %)	60 % Unknown (10 %)	No	Unknown	Yes	Yes	Yes	Yes	Yes
Surgery	M 90 %	M	M	M	Q	M	M	M
Radiotherapy	50 %	No	No	No	Yes	No	No	No
Chemotherapy	60 % Unknown (10 %)	Yes	Yes	Yes	Unknown	Yes	No	Yes
Endocrine therapy	90 % Unknown (10 %)	Yes	Yes	Yes	Unknown	Yes	Unknown	Yes
Trastuzumab	10 % Unknown (10 %)	No	No	No	Unknown	No	No	No
Relapse	20 %	Yes	No	Yes	Yes	Unknown	No	No
Other tumors	20 %	Yes	No	No	Yes	Yes	No	No
Follow-up (days)	3152 [701–6735]	1795	3845	2892	1096	7069	1031	918

For single patients, age is reported as decade range to maintain participant confidentiality
Abbreviations: BMI body mass index, ER estrogen receptor, HR hormone receptor, M mastectomy, PgR progesterone receptor, Q quadrantectomy, UVS unknown variant sequence

ISSN: 1471-2407