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Table 2 Characteristics of patients with known BRCA status

From: Long-term survival and BRCA status in male breast cancer: a retrospective single-center analysis

Characteristics BRCA-negative BRCA1-positive BRCA2-positive BRCA UVS
  n = 10 n = 1 Patient 1 Patient 2 Patient 3 Patient 4 Patient 5 n = 1
Age at diagnosis 61.0 [53.8–67.3] 30–40 60–70 70–80 70–80 60–70 70–80 70–80
BMI 26.2 [23.6–32.0] 22.8 24.5 33.6 27.0 23.2 31.4 25.8
Family history 50 % Yes No Yes No No Yes No
Smoke 0 % No Yes No Yes No No No
Alcohol intake 10 % No Yes No No No Yes No
Obesity 20 % No No Yes No No Yes No
Side Left (70 %); Right (30 %) Right Right Right Left Both Left Left
Stage I (20 %); II (70 %); III (10 %) II I III III Unknown I I
Histotype Ductal (100 %) Ductal Ductal Ductal Ductal Ductal Ductal Ductal
HR status ER+/PgR+ 9 ER+/PgR ER+/PgR ER+/PgR ER+/PgR ER+/PgR ER+/PgR ER+/PgR
Unknown 1 + + + + + + +
Node status, positive 50 % Yes No Yes Yes No No No
HER-2 positive 10 %
Unknown (10 %)
No No No Yes No No No
Ki-67 high-level (cutoff 20 %) 60 %
Unknown (10 %)
No Unknown Yes Yes Yes Yes Yes
Surgery M 90 % M M M Q M M M
Radiotherapy 50 % No No No Yes No No No
Chemotherapy 60 %
Unknown (10 %)
Yes Yes Yes Unknown Yes No Yes
Endocrine therapy 90 %
Unknown (10 %)
Yes Yes Yes Unknown Yes Unknown Yes
Trastuzumab 10 %
Unknown (10 %)
No No No Unknown No No No
Relapse 20 % Yes No Yes Yes Unknown No No
Other tumors 20 % Yes No No Yes Yes No No
Follow-up (days) 3152 [701–6735] 1795 3845 2892 1096 7069 1031 918
  1. For single patients, age is reported as decade range to maintain participant confidentiality
  2. Abbreviations: BMI body mass index, ER estrogen receptor, HR hormone receptor, M mastectomy, PgR progesterone receptor, Q quadrantectomy, UVS unknown variant sequence