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Table 3 Imbalances of baseline characteristics between right- and left-sided colon cancer patients

From: Better survival in right-sided versus left-sided stage I - III colon cancer patients

   Logistic regression in raw data (N = 91,4166)a Patient characteristics after stratified bipartite propensity score matching (N = 90,067)c
   OR (95 % CI) Pb Total Right-sided carcinoma Left-sided carcinoma Pb
N = 90,067 N = 51,331 N = 38,736
Tumor stage Stage I D)   24,924 (27.7 %) 13,622 (26.5 %) 11,302 (29.2 %) E)
(AJCC 6th ed.) Stage II    33,002 (36.6 %) 19,790 (38.6 %) 13,212 (34.1 %)  
  Stage III    32,141 (35.7 %) 17,919 (34.9 %) 14,222 (36.7 %)  
T-stage T1 Reference <0.001 11387.4 (12.6 %) 6378 (12.4 %) 5009.4 (12.9 %) 0.908
  T2 1.45 (1.36–1.55)   17213.6 (19.1 %) 9360 (18.2 %) 7853.6 (20.3 %)  
  T3 1.15 (1.08–1.22)   50984.6 (56.6 %) 29,704 (57.9 %) 21280.6 (54.9 %)  
  T4 1.08 (1.00–1.17)   10481.4 (11.6 %) 5889 (11.5 %) 4592.4 (11.9 %)  
Number of positive 0 Reference <0.001 57,926 (64.3 %) 33,412 (65.1 %) 24,514 (63.3 %) 0.733
Regional lymph 1 0.82 (0.78–0.87)   10303.2 (11.4 %) 5579 (10.9 %) 4724.2 (12.2 %)  
Nodes 2–3 0.82 (0.77–0.86)   9909.2 (11.0 %) 5631 (11.0 %) 4278.2 (11.0 %)  
  4–6 0.87 (0.81–0.93)   6433.9 (7.1 %) 3650 (7.1 %) 2783.9 (7.2 %)  
  7+ 0.94 (0.86–1.01)   5494.7 (6.1 %) 3059 (6.0 %) 2435.7 (6.3 %)  
Number of retrieved <12 Reference <0.001 18327.7 (20.3 %) 10,240 (19.9 %) 8087.7 (20.9 %) 0.931
Regional lymph 12–16 1.72 (1.64–1.80)   25,713 (28.5 %) 14,813 (28.9 %) 10,900 (28.1 %)  
Nodes 17+ 2.44 (2.33–2.55)   46026.3 (51.1 %) 26,278 (51.2 %) 19748.3 (51.0 %)  
Grading G1 Reference <0.001 8274.1 (9.2 %) 4667 (9.1 %) 3607.1 (9.3 %) 0.954
  G2 0.97 (0.91–1.02)   60851.4 (67.6 %) 34,630 (67.5 %) 26221.4 (67.7 %)  
  G3 1.74 (1.62–1.87)   16543.4 (18.4 %) 9599 (18.7 %) 6944.4 (17.9 %)  
  G4 1.92 (1.64–2.24)   1738.2 (1.9 %) 1035 (2.0 %) 703.2 (1.8 %)  
  Unknown 0.92 (0.82–1.03)   2659.8 (3.0 %) 1400 (2.7 %) 1259.8 (3.3 %)  
Histology Adenocarcinoma Reference <0.001 62172.7 (69.0 %) 35,607 (69.4 %) 26565.7 (68.6 %) 0.978
  Adeno-Ca in adenomatous polyp 0.95 (0.89–1.02)   5139.1 (5.7 %) 2883 (5.6 %) 2256.1 (5.8 %)  
  Adeno-Ca in villous adenoma 2.02 (1.82–2.25)   2901.7 (3.2 %) 1664 (3.2 %) 1237.7 (3.2 %)  
  Adeno-Ca in tubulovillous adenoma 1.73 (1.62–1.85)   8333.5 (9.3 %) 4806 (9.4 %) 3527.5 (9.1 %)  
  Mucinous carcinoma 2.23 (2.10–2.37)   11,520 (12.8 %) 6371 (12.4 %) 5149 (13.3 %)  
CEA C0-stage Reference <0.001 31640.5 (35.1 %) 18,476 (36.0 %) 13164.5 (34.0 %) 0.763
  C1-stage 0.88 (0.83–0.92)   17236.6 (19.1 %) 9804 (19.1 %) 7432.6 (19.2 %)  
  Unknown/Borderline 1.00 (0.96–1.04)   41189.8 (45.7 %) 23,051 (44.9 %) 18138.8 (46.8 %)  
Operation Segmental resection Reference <0.001 13557.3 (15.1 %) 7750 (15.1 %) 5807.3 (15.0 %) 0.447
  Hemi/subtotal colectomy 14.3 (13.8–14.8)   75781.8 (84.1 %) 43,171 (84.1 %) 32610.8 (84.2 %)  
  Other 2.66 (2.32–3.05)   727.9 (0.8 %) 410 (0.8 %) 317.9 (0.8 %)  
Year 2004 to 2006 Reference 0.285 31,052 (34.5 %) 17,527 (34.1 %) 13,525 (34.9 %) E)
  2007 to 2009 0.97 (0.93–1.01)   30,869 (34.3 %) 17,585 (34.3 %) 13,284 (34.3 %)  
  2010 to 2012 0.97 (0.93–1.01)   28,146 (31.3 %) 16,219 (31.6 %) 11,927 (30.8 %)  
Age Up to 49 years Reference <0.001 5545.6 (6.2 %) 3174 (6.2 %) 2371.6 (6.1 %) 0.995
  50 to 64 years 1.56 (1.46–1.66)   21581.8 (24.0 %) 12,332 (24.0 %) 9249.8 (23.9 %)  
  65 to 79 years 2.65 (2.49–2.83)   37577.3 (41.7 %) 21,253 (41.4 %) 16324.3 (42.1 %)  
  80+ years 4.08 (3.80–4.39)   25362.3 (28.2 %) 14,572 (28.4 %) 10790.3 (27.9 %)  
Gender male Reference <0.001 40730.6 (45.2 %) 22,954 (44.7 %) 17776.6 (45.9 %) 0.570
  female 1.30 (1.26–1.35)   49336.4 (54.8 %) 28,377 (55.3 %) 20959.4 (54.1 %)  
Ethnicity Caucasian Reference <0.001 72714.5 (80.7 %) 41,771 (81.4 %) 30943.5 (79.9 %) 0.050
  African-American 1.09 (1.04–1.15)   11763.1 (13.1 %) 6213 (12.1 %) 5550.1 (14.3 %)  
  Other/Unknown 0.66 (0.62–0.70)   5589.4 (6.2 %) 3347 (6.5 %) 2242.4 (5.8 %)  
Marital status Married Reference 0.877 47284.7 (52.5 %) 27,005 (52.6 %) 20279.7 (52.4 %) 0.930
  Single 0.98 (0.93–1.03)   10609.8 (11.8 %) 6044 (11.8 %) 4565.8 (11.8 %)  
  Widowed 1.00 (0.95–1.05)   20331.9 (22.6 %) 11,580 (22.6 %) 8751.9 (22.6 %)  
  Other/Unknown 0.99 (0.94–1.05)   11840.6 (13.1 %) 6702 (13.1 %) 5138.6 (13.3 %)  
  1. aMultivariable logistic regression with the odds ratio (OR) for right-sided carcinomas in the original raw data set (N = 91,416)
  2. AJCC American Joint Committee on Cancer, T-stage tumor stage, CEA Carcinoembryonic antigen
  3. bLikelihood ratio tests
  4. cAfter full bipartite propensity score matching with stratification for year of diagnosis and tumor stage, a multivariable conditional logistic regression based on the subgroups obtained by the matching procedure was performed. No significant bias was observed for cancer side
  5. 1349 patients were excluded because of lacking counterpart in the other group
  6. Weighted matching causes decimals for the number of patients in the group with left-sided cancer
  7. D)Excluded to avoid collinearity with the number of positive regional lymph nodes
  8. E)No statistical test because propensity score matching was stratified for year of diagnosis and tumor stage