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Table 4 Regression models for outcome variables a) palliative care concerns (total MyPOS score), b) global quality of life (EORTCQLQ-C30 subscale), and c) generic health-related quality of life (EQ5D Index score) and their association with demographic, clinical characteristics and symptom burden (n = 557)

From: The impact of disease-related symptoms and palliative care concerns on health-related quality of life in multiple myeloma: a multi-centre study

 

Palliative care concerns

Global quality of life QLQ-C30

EQ5D Index

Independent variables

Coefficient

Lower CI

Upper CI

Coefficient

Lower CI

Upper CI

Coefficient

Lower CI

Upper CI

(Constant)

20.639**

14.189

27.089

105.788**

100.986

110.589

1.168**

1.093

1.242

General symptom level

1.439**

1.136

1.741

–

–

–

–

–

–

Pain

0.046*

0.016

0.076

−2.572*

−4.168

−0.975

−0.100**

−0.129

−0.071

Weakness/lack of energy

–

–

–

−5.741**

−7.395

−4.086

–

–

–

Drowsiness

–

–

–

–

–

–

0.032

0.000

0.064

Dry mouth

1.395**

0.558

2.233

–

–

–

–

–

–

HADS Anxiety

1.100**

0.891

1.308

−2.519*

−4.091

−0.947

–

–

–

HADS Depression

–

–

–

−3.749**

−5.446

−2.052

−0.075**

−0.102

−0.048

Age

−0.136**

−0.204

−0.069

–

–

–

–

–

–

Being in the stable/plateau phasea

−2.693**

−4.096

−1.290

4.804**

2.127

7.482

–

–

–

ECOG performance status 2b

–

–

–

−3.654

−7.449

0.141

–

–

–

ECOG performance status 3/4 – limited self-care or completely disabledc

–

–

–

–

–

–

−0.159**

−0.248

−0.070

Physical function/Poor mobility

−0.138**

−0.174

−0.101

−5.085**

−6.610

−3.560

−0.082**

−0.110

−0.054

Adjusted R2

0.879

  

0.514

  

0.584

  

F, P

F = 192.205

P < 0.001

 

F = 85.522

P < 0.001

 

F = 61.924

P < 0.001

 
  1. ECOG Eastern Cooperative Oncology Group performance status, CI confidence interval, EQ5D EuroQol-5D-3L, HADS Hospital Anxiety and Depression Scale, MyPOS Myeloma Patient Outcome Scale
  2. aReference group is patients being unstable, i.e. newly diagnosed or having relapsed, progressive or palliative disease or being in a treatment-interval
  3. bReference group is ECOG performance status of 0
  4. cReference group is ECOG performance status of 0
  5. *p < 0.05
  6. **p < 0.001