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Table 1 Cardiotoxicity of capecitabine, 5-Fluorouracil, TAS 102 and S1

From: TAS-102, the first “cardio-gentle” fluoropyrimidine in the colorectal cancer landscape?

  Very common Common Uncommon Rare
Capecitabine    Unstable angina pectoris, angina pectoris, myocardial ischemia, atrial fibrillation, cardiac arrhythmia, tachycardia, Palpitation Ventricular fibrillation, QT prolongation, torsade de pointes, bradycardia, vasospasm
5-fluorouracil   Chest pain Myocardial infarction, myocardial ischemia, cardiac arrhythmia, myocarditis, heart failure, dilated cardiomyopathy Cardiac arrest, sudden cardiac death
TAS-102     Myocardial infarction, myocardial ischemia, chest pain, bradycardia, tachycardia
S1    Cardiac failure, acute myocardial infarction, pericardial effusion, atrial fibrillation, angina pectoris, cardiac fibrillation, tachycardia, palpitations