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Table 4 p53 detection analysis

From: Molecular analyses of unselected head and neck cancer cases demonstrates that human papillomavirus transcriptional activity is positively associated with survival and prognosis

Sample ID Anatomical site L1 DNA HPV 16 E6/E7 DNA HPV 16 mRNA p53 PCR Smokers
2 Oropharynx 6 +
5 Larynx 16
7 Hypopharynx +
8 Other +
9 Oropharynx 6, 16 +
12 Other 6, 11
17 Oropharynx Mixed +
18 Larynx +
26 Larynx 6 +
39 Oropharynx 16 +
50 Oropharynx 16 + +
52 Hypopharynx 16 +
10 Larynx 6 +
14 Larynx + +
15 Larynx + +
16 Oral cavity 40 + +
33 Larynx 16 + + + +
35 Hypopharynx 16 + +
36 Larynx 16 + + + +
41 Oropharynx 16, mixed + + +
54 Larynx + +
  1. Amplicons spanning the entire p53 open reading frame were amplified from 6/9 HPV 16 E6/E7 mRNA positive HNSCCs (bottom), but only 2/12 transcript negative samples (top) (p = 0.032, Fisher’s exact test; OR 10). HPV16 DNA or P16INK4a showed no relationship with p53 PCR