| Protein | mRNA | ||||
---|---|---|---|---|---|---|
 | Stomach | Colon and rectum | GC vs. CRC, % difference (p b) | Stomach | Colon and rectum | GC vs. CRC, % difference (p b) |
UIa in paired samples; upregulated pair, n/total pair, n (%) | Â | |||||
  HNRNPA1 or HNRNPA1 | 31/60 (52) | 106/121 (88) | 36 (< 0.001) | 20/45 (44) | 55/96 (57) | 13 (0.214) |
  SRSF1 or SRSF1 | 13/60 (22) | 38/121 (31) | 10 (0.232) | 17/45 (38) | 37/96 (39) | 1 (0.921) |
  SRSF3 or SRSF3 | 20/60 (33) | 89/121 (74) | 40 (< 0.001) | 20/45 (44) | 46/96 (48) | 3 (0.838) |
  SRSF5 or SRSF5 | 15/60 (25) | 48/121 (40) | 15 (0.074) | 16/45 (36) | 20/96 (21) | −15 (0.097) |
  SRSF6 or SRSF6 | 17/60 (28) | 63/121 (52) | 24 (0.004) | 16/45 (36) | 46/96 (48) | 12 (0.232) |
  SRSF7 or SRSF7 | 25/60 (42) | 69/121 (57) | 15 (0.115) | 18/45 (40) | 45/96 (47) | 7 (0.559) |
  CEA | 32/60 (53) | 111/121 (92) | 38 (< 0.001) | – | – | – |
Detection accuracy, AUC | Â | Â | Â | Â | Â | Â |
 Allc (Sensitivity%/Specificity%) | n = 147 | n = 258 |  | n = 111 | n = 202 |  |
 low-stage ACd | n = 127 | n = 197 |  | n = 95 | n = 153 |  |
 high-stage ACd | n = 103 | n = 193 |  | n = 78 | n = 152 |  |
  HNRNPA1 or HNRNPA1 | 0.74 (72/71) | 0.90e (85/86) | 17 (< 0.001) | 0.58e,f (69/50) | 0.69e,f (54/78) | 11 (0.117) |
 | 0.71 | 0.93 | 23 (< 0.001) | 0.54e | 0.71e,f | 17 (0.030) |
 | 0.77 | 0.89e | 11 (0.141) | 0.64e | 0.64e,f | 0 (1.000) |
  SRSF1 or SRSF1 | 0.58e,f (95/23) | 0.62e,f (42/82) | 4 (0.487) | 0.55e,f (49/65) | 0.61e,f (88/35) | 6 (0.399) |
 | 0.56e | 0.66e,f | 10 (0.147) | 0.53e | 0.62e,f | 9 (0.252) |
 | 0.66e | 0.58e,f | −8 (0.314) | 0.63e | 0.58e,f | −6 (0.552) |
  SRSF3 or SRSF3 | 0.53e,f (53/57) | 0.84e,f (81/78) | 32 (<0.001) | 0.59e,f (71/52) | 0.65e,f (75/51) | 7 (0.322) |
 | 0.56e,f | 0.84e,f | 28 (< 0.001) | 0.54e | 0.68e,f | 14 (0.069) |
 | 0.55e,f | 0.84e | 29 (< 0.001) | 0.60e | 0.62e,f | 16 (0.866) |
  SRSF5 or SRSF5 | 0.51e,f (60/51) | 0.62e,f (35/89) | 11 (0.062) | 0.52e,f (91/23) | 0.52e,f (78/38) | 0 (0.953) |
 | 0.53e,f | 0.65e,f | 12 (0.101) | 0.54e | 0.51e,f | −3 (0.718) |
 | 0.62e | 0.58e,f | −3 (0.701) | 0.53e,f | 0.54e,f | 1 (0.914) |
  SRSF6 or SRSF6 | 0.61e,f (38/89) | 0.76e,f (51/96) | 14 (0.006) | 0.58e,f (56/62) | 0.67e,f (60/68) | 9 (0.192) |
 | 0.60e | 0.78e,f | 18 (0.004) | 0.53e,f | 0.68e,f | 15 (0.062) |
 | 0.56e,f | 0.74e,f | 18 (0.032) | 0.61e | 0.65e,f | 4 (0.699) |
  SRSF7 or SRSF7 | 0.63e (30/84) | 0.74e,f (59/83) | 11 (0.066) | 0.54e,f (38/80) | 0.65e,f (85/43) | 11 (0.125) |
 | 0.61e | 0.75e,f | 15 (0.036) | 0.53e | 0.66e,f | 12 (0.126) |
 | 0.71e | 0.73e,f | 3 (0.755) | 0.70e | 0.64e,f | −6 (0.474) |
  CEA | 0.76 (57/89) | 0.96f (92/94) | 20 (< 0.001) | – | – | – |
 | 0.77g | 0.97 | 20 (< 0.001) | – | – | – |
 | 0.90g | 0.99f | 9 (0.037) | – | – | – |