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Table 1 Demographic characteristics of subjects and tumors

From: Comparative expression patterns and diagnostic efficacies of SR splicing factors and HNRNPA1 in gastric and colorectal cancer

  Stomach (n = 147) Colon and rectum (n = 273)
    SFa (p a)    SFa (p a)
Total (n = 420)    Mediana (IQR)    Mediana (IQR)
Sample constitution       
 Cancer 60    123   
 Adenoma    15   
 NM 87    135   
Sample pairing, n (GC/NM)    (CRC/adenoma/NM)   
 Doubletb 60 (60/60)    120 (113/7/120)   
 Tripletc    8 (8/8/8)   
 Unpaired (singlet) 27 (0/27)    9 (2/0/7)   
Subjects (n = 224), n 87    137   
Age, mean (range), years 66 (40–86)   NS-all SFs 69 (45–90)   NS-all SFs
 ≥65 years, n (%) 32 (53)    87 (71)   
Gender, male, n (%) 90 (61)   NS-all SFs 193 (71)   NS-all SFs
Type of cancer, n       
  AC 56   AC 120  
  Otherd 4   Othere 3  
Location of AC, n (%)    NS-all SFs    NS-all SFs
  Cardia 5 (9)   Proximalf 29 (24)  
  Body 13 (23)   Distalf 63 (53)  
  Antrum 38 (68)   Rectum 28 (23)  
Histologic feature of AC, n (%) Type   SRSF7 (0.049) Differentiation   HNRNPA1 (0.020)
  Intestinal 44 (79) 7.0 (2.0–29.0) Well 37 (31) 7.0 (4.2–11.0)
  Diffuseg 12 (21) 2.9 (1.9–4.8) Moderate 83 (69) 5.0 (2.1–8.0)
     and poor   
Tumor status of AC, n (%)    NS-all SFs    NS-all SFs
 T1, T2 27 (48)   19 (16)  
 T3, T4 29 (52)   101 (84)  
LN metastasis of AC, n (%)    NS-all SFs    HNRNPA1 (0.003)
 N0 28 (50)   62 (52)   7.0 (4.0–10.0)
 N1, N2, N3 28 (50)   58 (48)   4.3 (1.9–7.5)
TNM stageh of AC, n (%)    NS-all SFs    HNRNPA1 (0.003)
 I, II 40 (71)   62 (52)   7.0 (4.0–10.0)
 III, IV 16 (29)   58 (48)   4.3 (1.9–7.5)
Aneuploidy status of AC, n (%)    NS-all SFs    NS-all SFs
 ≤ 3 % 50 (91)   72 (66)  
 > 3 % 5 (9)   37 (34)  
  1. Abbreviations: AC adenocarcinoma, CRC colorectal cancer, CEA carcinoembryonic antigen, GC gastric cancer, IQR interquartile range, LN lymph node, NM normal mucosa, NS-all SFs not significant (p >0.05) for all splicing factor proteins and their mRNAs; SF = splicing factor
  2. aSF name, p values, and median relative band intensity were described only for SF proteins or mRNAs that had a p value less than 0.05 in the six SFs; p values were acquired by Mann-Whitney U-test (between two groups) or Kruskal-Wallis test
  3. bTwo samples (cancer with its adjacent NM or adenoma with its adjacent NM) acquired from the same patient
  4. cThree samples (cancer, adenoma, and their adjacent NM) were acquired from the same patient
  5. dGastrointestinal stromal tumor (n = 3) and neuroendocrine carcinoma (n = 1)
  6. eLymphoma (n = 2) and malignant melanoma (n = 1)
  7. fProximal colon indicates cecum, ascending colon, and transverse colon. Distal colon indicates splenic flexure, descending colon, sigmoid colon, and rectosigmoid junction
  8. gFive cases of mixed type were included
  9. hTNM stage was determined based on the 7th edition of AJCC/UICC TNM classification. Low- and high-stage indicate TNM stage I/II and III/IV, respectively