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Table 1 Demographic characteristics of subjects and tumors

From: Comparative expression patterns and diagnostic efficacies of SR splicing factors and HNRNPA1 in gastric and colorectal cancer

 

Stomach (n = 147)

Colon and rectum (n = 273)

   

SFa (p a)

  

SFa (p a)

Total (n = 420)

  

Mediana (IQR)

  

Mediana (IQR)

Sample constitution

      

 Cancer

60

  

123

  

 Adenoma

–

  

15

  

 NM

87

  

135

  

Sample pairing, n

(GC/NM)

  

(CRC/adenoma/NM)

  

 Doubletb

60 (60/60)

  

120 (113/7/120)

  

 Tripletc

–

  

8 (8/8/8)

  

 Unpaired (singlet)

27 (0/27)

  

9 (2/0/7)

  

Subjects (n = 224), n

87

  

137

  

Age, mean (range), years

66 (40–86)

 

NS-all SFs

69 (45–90)

 

NS-all SFs

 ≥65 years, n (%)

32 (53)

  

87 (71)

  

Gender, male, n (%)

90 (61)

 

NS-all SFs

193 (71)

 

NS-all SFs

Type of cancer, n

      
 

AC

56

 

AC

120

 
 

Otherd

4

 

Othere

3

 

Location of AC, n (%)

  

NS-all SFs

  

NS-all SFs

 

Cardia

5 (9)

 

Proximalf

29 (24)

 
 

Body

13 (23)

 

Distalf

63 (53)

 
 

Antrum

38 (68)

 

Rectum

28 (23)

 

Histologic feature of AC, n (%)

Type

 

SRSF7 (0.049)

Differentiation

 

HNRNPA1 (0.020)

 

Intestinal

44 (79)

7.0 (2.0–29.0)

Well

37 (31)

7.0 (4.2–11.0)

 

Diffuseg

12 (21)

2.9 (1.9–4.8)

Moderate

83 (69)

5.0 (2.1–8.0)

    

and poor

  

Tumor status of AC, n (%)

  

NS-all SFs

  

NS-all SFs

 T1, T2

27 (48)

 

–

19 (16)

 

–

 T3, T4

29 (52)

 

–

101 (84)

 

–

LN metastasis of AC, n (%)

  

NS-all SFs

  

HNRNPA1 (0.003)

 N0

28 (50)

 

–

62 (52)

 

7.0 (4.0–10.0)

 N1, N2, N3

28 (50)

 

–

58 (48)

 

4.3 (1.9–7.5)

TNM stageh of AC, n (%)

  

NS-all SFs

  

HNRNPA1 (0.003)

 I, II

40 (71)

 

–

62 (52)

 

7.0 (4.0–10.0)

 III, IV

16 (29)

 

–

58 (48)

 

4.3 (1.9–7.5)

Aneuploidy status of AC, n (%)

  

NS-all SFs

  

NS-all SFs

 ≤ 3 %

50 (91)

 

–

72 (66)

 

–

 > 3 %

5 (9)

 

–

37 (34)

 

–

  1. Abbreviations: AC adenocarcinoma, CRC colorectal cancer, CEA carcinoembryonic antigen, GC gastric cancer, IQR interquartile range, LN lymph node, NM normal mucosa, NS-all SFs not significant (p >0.05) for all splicing factor proteins and their mRNAs; SF = splicing factor
  2. aSF name, p values, and median relative band intensity were described only for SF proteins or mRNAs that had a p value less than 0.05 in the six SFs; p values were acquired by Mann-Whitney U-test (between two groups) or Kruskal-Wallis test
  3. bTwo samples (cancer with its adjacent NM or adenoma with its adjacent NM) acquired from the same patient
  4. cThree samples (cancer, adenoma, and their adjacent NM) were acquired from the same patient
  5. dGastrointestinal stromal tumor (n = 3) and neuroendocrine carcinoma (n = 1)
  6. eLymphoma (n = 2) and malignant melanoma (n = 1)
  7. fProximal colon indicates cecum, ascending colon, and transverse colon. Distal colon indicates splenic flexure, descending colon, sigmoid colon, and rectosigmoid junction
  8. gFive cases of mixed type were included
  9. hTNM stage was determined based on the 7th edition of AJCC/UICC TNM classification. Low- and high-stage indicate TNM stage I/II and III/IV, respectively
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BMC Cancer

ISSN: 1471-2407

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