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Fig. 3 | BMC Cancer

Fig. 3

From: 3D culture of Her2+ breast cancer cells promotes AKT to MAPK switching and a loss of therapeutic response

Fig. 3

3D culture attenuates response to tamoxifen, fulvestrant and trastuzumab. BT474 (a) and MDAMB361 (b) cells were grown in 2D (SQUARE) or 3D (CIRCLE) cultures in the presence or absence of tamoxifen, fulvestrant or trastuzumab for 7 days after which cell number was assessed by Coulter counting. For both cell lines, culture in 3D conditions attenuated their response to endocrine agent or trastuzumab. Plots are mean cell growth ± SD

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BMC Cancer

ISSN: 1471-2407

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