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Fig. 6 | BMC Cancer

Fig. 6

From: Systematic interactome mapping of acute lymphoblastic leukemia cancer gene products reveals EXT-1 tumor suppressor as a Notch1 and FBWX7 common interactor

Fig. 6

Genes coregulated by EXT1 and FBXW7. a HeLa Notch∆E-eGFP were treated siRNA for EXT1, FBXW7 or a control siRNA. Relative mRNA expression levels of EXT1 and FBXW7 were then analyzed by qPCR and RNA samples subjected to high throughput Illumina sequencing (RNA-seq). Ven diagrams represent a comparison between deregulated genes following knock down of EXT1 or FBXW7. b Relative mRNA expression levels of EXT1 and FBXW7 analyzed by qPCR. c Gene ontology enrichment analysis of common deregulated genes. GO-terms and node sizes are proportional to the number of genes implicated in the same GO term

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