Fig. 1
From: Selective mode of action of plumbagin through BRCA1 deficient breast cancer stem cells
ALDH1+ cells and not ALDH1- cells from BRCA1-defective breast cancer cell lines can form spheres. Graph showing the percentages of SP (a), CD44+/24–/low (b) and ALDH1+ (c) cells among the various breast cancer cell lines employed in this study. By all these three methods of identification, the CSC population was significantly higher in BRCA1-defective HCC1937 when compared to HCC1937/wt BRCA1. d and (e) A comparison of the in vitro sphere forming ability of ALDH1+ and ALDH1- cells from various cell lines indicating the inability of ALDH1- cells from BRCA1-defective cell lines to form spheres thus supporting that the ALDH1+ population from these cell lines entirely represents the BCSCs. Scale = 100 μm