Fig. 1
From: Safety and feasibility of fasting in combination with platinum-based chemotherapy
Schema of the trial design; cohorts and strategy for escalating fasting duration. R24r signifies 24 hours of fasting without planned food, only rescue. R48r is 48 hours of fasting prior to chemotherapy, without planned food, only rescue. If safety or feasibility failed in the cohort of 48 hours fasting, we planned a “de-escalation” to a 48 hour fasting period with planned rescue food: R48p. However, if 48 hours fasting was safe and feasible, we would escalate to 72 hours fasting, broken down as 48 hours before chemotherapy and 24 hours after, R48/24r