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Table 1 Hereditary and Selected Environmental Risk Factors among Inflammatory Breast Cancer Cases and Comparison Groups

From: Importance of hereditary and selected environmental risk factors in the etiology of inflammatory breast cancer: a case-comparison study

  GWU IBCa Cases GWU BCa Cases UT OCb Cases OC Casesc BRCA OC Casesd non-BRCA UTb Controls WHI BCe Cases WHIe Controls CGEMS BCf Cases CGEMSf Controls
  n = 141 (%) n = 178 (%)g n = 260 (%) n = 96 (%) n = 164 (%) n = 331 (%) n = 465 (%)g n = 9317 (%)g n = 1145 (%) n = 1142 (%)
Average Age at Study Entry 50.3 53.8 59.2 57.9 60.1 52.2 67.0 67.0 65.4h 65.6h
Average Age at Diagnosis 48.3 51.8 56.1 54.6 57.1 NA 73.6 NA Unavailablei NA
Average Body Mass Index (Kg/m2) 28.9 26.5 24.5 24.3 24.5 24.9 30.2 28.8   
First-Degree Breast Cancer Family History           
Yes 24 (17.0) 43 (24.4) 63 (24.2) 33 (34.4) 30 (18.3) 37 (11.2) 74 (16.9) 1105 (12.6) 274 (23.9) 204 (17.9)
Parity (≥1 Pregnancy)           
Yes 114 (80.9) 130 (73.9) 233 (89.6) 89 (92.7) 144 (87.8) 286 (86.4) 418 (90.1) 8661 (93.1)   
Oral Contraceptive Use           
Yes 113 (80.1) 125 (71.0) 101 (38.8) 43 (44.8) 58 (35.4) 216 (65.3) 159 (34.2) 3089 (33.1)   
Regular Alcohol Use (≥1 drink per day)           
Yes 30 (21.3) 32 (18.2) 35 (13.5) 16 (16.7) 19 (11.6) 42 (12.7) 69 (15.2) 1184 (12.8)   
  1. a Inflammatory breast cancer (IBC) and non-inflammatory breast cancer (BC) cases recruited at George Washington University (GWU). All subjects recruited at GWU and included in this study were Caucasian. Subjects were recruited within an average of two years post diagnosis
  2. b Ovarian Cancer (OC) cases and controls obtained from hospital-based case–control study conducted at University of Toronto (UT). All subjects recruited through the UT study were Caucasian and Ashkenazi Jewish
  3. c Ovarian cancer cases with an Ashkenazi Jewish founder mutation in the BRCA1 (185delAG and 5382insC) and BRCA2 (6184delT) genes
  4. d Ovarian cancer cases who tested negative for the three Ashkenazi Jewish founder mutations in the BRCA1 or BRCA2 genes
  5. e Breast cancer (BC) cases and controls obtained from the Hormone Therapy Trials of the population-based Women’s Health Initiative (WHI) cohort. All WHI cases and controls included in our study were Caucasian and 50 years of age or above at study entry
  6. f Breast Cancer (BC) cases and controls obtained from the Cancer Genetic Markers of Susceptibility (CGEMS) study conducted among participants in the population-based Nurses’ Health Initiative (NHS) cohort. All subjects in CGEMS were Caucasian and post-menopausal at recruitment
  7. g Percentages for some variables do not correspond to the total number of cases and controls due to “missing” answers
  8. h Estimated from age ranges provided as part of the secondary data as follows: <54, 55–59, 60–64, 65–69, 70–74, and ≥75
  9. i Average age of diagnosis was unavailable but all cases were reported to be post-menopausal at diagnosis and controls were matched to cases based on several criteria including age at diagnosis