Fig. 5

Graphs illustrating the damage intensity profile induced by each compound at the telomeric repeat sites in the PvuII-cleaved pUC19/T7 sequence. The graphs for (a) cisplatin, (b) transplatin, (c) 1,8 platinum, (d) 1,10 platinum and (e) 1,12 platinum, are highlighted in blue, red, green, purple and orange, respectively. The damage intensity (normalised to a value of up to 1, whereby a value of 1 was assigned to the base that yielded the most intense damage) was determined from the percentage of damage at each base in the telomeric sequence. The error bars represent the SEM, determined from three separate telomeric repeat sites – T4, T5 and T6. The six nucleotides of the telomeric repeat are referred to as T₁G₁G₂G₃AT₂