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Table 4 Estimated mean difference of cytokines serum levels between CC cases and controls stratified by genotypes

From: Risk allelic load in Th2 and Th3 cytokines genes as biomarker of susceptibility to HPV-16 positive cervical cancer: a case control study

Diagnosis βa coefficient (95 % CI)
Polymorphism Total without stratification Ancestral allele homozygote Heterozygote Minor allele homozygote
  IL-4 -590C > T (rs2243250)   CC CT TT
NCL   - - - -
CC   1.0 (0.696,1.307) 0.61 (0.269,0.970) 1.22 (0.713,1.736) 0.87 (0.214,1.539)
  IL-6 -573G > C (rs1800796)   GG GC CC
NCL   - - - -
CC   2.63 (2.063,3.199) 3.12 (2.261,3.994) 2.39 (1.567,3.230) 2.20 (0.367,4.042)
  IL-10 -592C > A (rs1800872)   CC CA AA
NCL   - - - -
CC   2.55 (2.255,2.859) 2.27 (1.805,2.737) 2.55 (2.063,3.04) 2.62 (1.911,3.333)
  IL-10 -819C > T (rs1800871)   CC CT TT
NCL   - - - -
CC   2.55 (2.255,2.859) 2.24 (1.760,2.722) 2.45 (1.980,2.927) 2.83 (2.111,3.555)
  IL-10 -1082A > G (rs1800896)   AA AG GG
NCL   - - - -
CC   2.55 (2.255,2.859) 2.48 (2.078,2.898) 2.77 (2.261,3.291) 1.13 (0.508,1.758)
  IFN-γ -1615C > T (rs2069705) CC CT TT
NCL   - - - -
CC   −2.58 (−3.286,-1.891) −2.80 (−3.687,-1.927) −2.61 (−3.929,-1-291) −1.7 (−6.097,2.685)
  TNF-α -308G > A (rs 1800629) GG GA AA
NCL   - - - -
CC   −0.94 (−1.026,-0.860) −0.91 (−1.003,-0.816) −1.08 (−1.30,-0.876) −1.33 (−1.85,-0.813)
  TGFB1 -509C > T (rs1800469) CC CT TT
NCL   - - - -
CC   13.4 (11.52,15.47) 19.5 (15.85,23.17) 11.2 (8.686,13.71) 8.7 (2.54,14.98)
  1. Bold text denotes significant p values (p < 0.05)
  2. aAdjusted by age, CC history and smoking history
  3. Levels of serum cytokines are expressed in pg/ml except TGFB1 (ng/ml)