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Table 2 Association analysis of SNP in promoter of IL-4, IL-6, IL-10, TGFβ-1, TNF-α, IFN-γ with CC

From: Risk allelic load in Th2 and Th3 cytokines genes as biomarker of susceptibility to HPV-16 positive cervical cancer: a case control study

Polymorphism

n (%) CC/(%) controls (n = 200/200)

ORc (95 % CI)

p Value*

IL-4 -590C > T (rs2243250)

Codominant model

  

 C/C

32 (16)/60 (30)

1

 

 C/T

87 (43.5)/102 (51)

1.50 (0.804–2.807)

0.2

 T/T

81 (40.5)/38 (19)

4.36 (2.166–8.803) b

0.0001

Dominant model

 C/C

32 (16)/60 (30)

1

 

 C/T + T/T

168 (84)/140 (70)

2.22 (1.238–3.987)

0.007

Recessive model

 C/C + C/T

119 (59.5)/162 (81)

1

 

 T/T

81 (40.5)/38 (19)

3.3 (1.909–5.707)

0.0001

Alleles

 C

151 (37.7)/222 (56)

1

 

 T

249 (62.25)/178 (44)

2.08 (1.475–2.934)

0.0001

p HWEa

  

0.6

IL-6 -573G > C (rs1800796)

Codominant model

  

 G/G

54 (27)/89 (44.5)

1

 

 G/C

85 (42.5)/91 (45.5)

1.47 (0.875–2.499)

0.14

 C/C

61 (30.5)/20 (10)

3.2 (1.572–6.535) b

0.001

Dominant model

  

 G/G

54 (27)/89 (44.5)

1

 

 G/C + C/C

146 (73)/111 (55.5)

1.82 (1.111–2.983)

0.017

Recessive model

 G/G + G/C

139 (69.5)/180 (90)

1

 

 C/C

61 (30.5)/20 (10)

2.58 (1.348–4.934)

0.004

Alleles

 C

193 (48.25)/269 (67.25)

1

 

 T

207 (51.75)/131 (32.75)

1.70 (1.208–2.404)

0.002

p HWEa

  

0.72

IL-10 -592C > A (rs1800872)

Codominant model

  

 C/C

44 (22)/85 (42.5)

1

 

 C/A

98 (49)/85 (42.5)

2.08 (1.190–3.656)

0.01

 A/A

58 (29)/30 (15)

3.28 (1.660–6.508) b

0.001

Dominant model

  

 C/C

44 (22)/85 (42.5)

1

 

 C/A + A/A

156 (78)/115 (57.5)

2.40 (1.416–4.072)

0.001

Recessive model

 C/C + C/A

142 (71)/170 (85)

1

 

 A/A

58 (29)/30 (15)

2.09 (1.166–3.756)

0.013

Alleles

 C

185 (46.37)/255 (63.75)

1

 

 A

214 (53.63)/145 (36.25)

1.87 (1.332–2.630)

0.0001

p HWEa

  

0.25

IL-10 -819C > T (rs 1800871)

Codominant model

  

 C/C

49 (24.5)/81 (40.5)

1

 

 C/T

97 (48.5)/85 (42.5)

1.88 (1.078–3.281)

0.02

 T/T

54 (27)/34 (17)

2.6 (1.330–5.116) b

0.005

Dominant model

 C/C

49 (24.5)/81 (40.5)

1

 

 C/T + T/T

151 (75.5)/119 (59.5)

2.08 (1.237–3.514)

0.006

Recessive model

 C/C + C/T

146 (73)/166 (83)

1

 

 T/T

54 (27)/34 (17)

1.77 (0.997–3.174)

0.05

Alleles

 C

195 (48.75)/247 (61.75)

1

 

 T

205 (51.25)/153 (38.25)

1.67 (1.192–2.353)

0.003

p HWEa

  

0.15

IL-10 -1082A > G (rs1800896)

Codominant model

  

 A/A

121 (60.5)/110 (55)

1

 

 A/G

70 (35)/78 (39)

0.73 (0.447–1.205)

0.22

 G/G

9 (4.5)/12 (6)

0.89 (0.298–2.659)

0.83

Dominant model

 A/A

121 (60.5)/110 (55)

1

 

 A/G + G/G

79 (39.5)/90 (45)

0.75 (0.466–1.210)

0.24

Recessive model

 A/A + A/G

191 (95.5)/188 (94)

1

 

 G/G

9 (4.5)/12 (6)

1.004 (0.342–2.944)

0.99

Alleles

 A

312 (78)/298 (74.5)

1

 

 G

88 (22)/102 (25.5)

0.83 (0.561–1.234)

0.36

p HWEa

  

0.7

TGFB1 -509C > T (rs1800469)

Codominant model

  

 C/C

61 (30.5)/80 (40)

1

 

 C/T

87 (43.5)/96 (48)

1.46 (0.854–2.514)

0.16

 T/T

52 (26)/24 (12)

3.73 (1.842–7.572) b

0.0001

Dominant model

  

 C/C

61 (30.5)/80 (40)

1

 

 C/T + T/T

139 (69.5)/120 (60)

1.91 (1.151–3.174)

0.01

Recessive model

 C/C + C/T

148 (74)/176 (88)

1

 

 T/T

52 (26)/24 (12)

2.98 (1.593–5.597)

0.001

Alleles

 C

209 (52.25)/256 (64)

1

 

 T

191 (47.75)/144 (36)

1.91 (1.354–2.701)

0.0001

p HWEa

  

0.55

TNFα -308G > A (rs 1800629)

Codominant model

  

 G/G

164 (82)/161 (80.5)

1

 

 G/A

26 (13)/36 (18)

0.55 (0.281–1.081)

0.08

 A/A

10 (5)/3 (1.5)

1.52 (0.305–7.631)

0.6

Dominant model

  

 G/G

164 (82)/161 (80.5)

1

 

 G/A + A/A

36 (18)/39 (19.5)

0.62 (0.332–1.187)

0.15

Recessive model

 

 G/G + G/A

190 (95)/197 (98.5)

1

 

 A/A

10 (5)/3 (1.5)

1.74 (0.356–8.519)

0.49

Alleles

 G

354 (88.5)/358 (89.5)

1

 

 A

46 (11.50)/42 (10.5)

0.74 (0.421–1.305)

0.3

p HWEa

  

0.54

IFN-γ -1615C > T (rs2069705)

Codominant model

  

 C/C

143 (71.5)/88 (44)

1

 

 C/T

51 (25.1)/91 (45.5)

0.25 (0.149–0.445)

0.0001

 T/T

6 (3)/21 (10.5)

0.11 (0.038–0.351) b

0.0001

Dominant model

  

 C/C

143 (71.5)/88 (44)

1

 

 C/T + T/T

57 (28.5)/112 (56)

0.22 (0.135–0.385)

0.0001

Recessive model

 C/C + C/T

194 (97)/179 (89.5)

1

 

 T/T

6 (3)/21 (10.5)

0.19 (0.068–0.581)

0.003

Alleles

 C

337 (84.25)/267 (66.75)

1

 

 T

63 (15.75)/133 (33.25)

0.30 (0.203–0.468)

0.0001

p HWEa

  

0.72

  1. Bold text denotes significant p values (p < 0.006)
  2. *p < =0.006 Multiples comparisons adjustment by Bonferroni method
  3. aHardy-Weinberg Equilibrium in controls
  4. bStatistically significant p value for trend (p < 0.001)
  5. cOdds Ratio adjusted by age, CC history and smoking history
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