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Table 2 Association analysis of SNP in promoter of IL-4, IL-6, IL-10, TGFβ-1, TNF-α, IFN-γ with CC

From: Risk allelic load in Th2 and Th3 cytokines genes as biomarker of susceptibility to HPV-16 positive cervical cancer: a case control study

Polymorphism n (%) CC/(%) controls (n = 200/200) ORc (95 % CI) p Value*
IL-4 -590C > T (rs2243250)
Codominant model   
 C/C 32 (16)/60 (30) 1  
 C/T 87 (43.5)/102 (51) 1.50 (0.804–2.807) 0.2
 T/T 81 (40.5)/38 (19) 4.36 (2.166–8.803) b 0.0001
Dominant model
 C/C 32 (16)/60 (30) 1  
 C/T + T/T 168 (84)/140 (70) 2.22 (1.238–3.987) 0.007
Recessive model
 C/C + C/T 119 (59.5)/162 (81) 1  
 T/T 81 (40.5)/38 (19) 3.3 (1.909–5.707) 0.0001
Alleles
 C 151 (37.7)/222 (56) 1  
 T 249 (62.25)/178 (44) 2.08 (1.475–2.934) 0.0001
p HWEa    0.6
IL-6 -573G > C (rs1800796)
Codominant model   
 G/G 54 (27)/89 (44.5) 1  
 G/C 85 (42.5)/91 (45.5) 1.47 (0.875–2.499) 0.14
 C/C 61 (30.5)/20 (10) 3.2 (1.572–6.535) b 0.001
Dominant model   
 G/G 54 (27)/89 (44.5) 1  
 G/C + C/C 146 (73)/111 (55.5) 1.82 (1.111–2.983) 0.017
Recessive model
 G/G + G/C 139 (69.5)/180 (90) 1  
 C/C 61 (30.5)/20 (10) 2.58 (1.348–4.934) 0.004
Alleles
 C 193 (48.25)/269 (67.25) 1  
 T 207 (51.75)/131 (32.75) 1.70 (1.208–2.404) 0.002
p HWEa    0.72
IL-10 -592C > A (rs1800872)
Codominant model   
 C/C 44 (22)/85 (42.5) 1  
 C/A 98 (49)/85 (42.5) 2.08 (1.190–3.656) 0.01
 A/A 58 (29)/30 (15) 3.28 (1.660–6.508) b 0.001
Dominant model   
 C/C 44 (22)/85 (42.5) 1  
 C/A + A/A 156 (78)/115 (57.5) 2.40 (1.416–4.072) 0.001
Recessive model
 C/C + C/A 142 (71)/170 (85) 1  
 A/A 58 (29)/30 (15) 2.09 (1.166–3.756) 0.013
Alleles
 C 185 (46.37)/255 (63.75) 1  
 A 214 (53.63)/145 (36.25) 1.87 (1.332–2.630) 0.0001
p HWEa    0.25
IL-10 -819C > T (rs 1800871)
Codominant model   
 C/C 49 (24.5)/81 (40.5) 1  
 C/T 97 (48.5)/85 (42.5) 1.88 (1.078–3.281) 0.02
 T/T 54 (27)/34 (17) 2.6 (1.330–5.116) b 0.005
Dominant model
 C/C 49 (24.5)/81 (40.5) 1  
 C/T + T/T 151 (75.5)/119 (59.5) 2.08 (1.237–3.514) 0.006
Recessive model
 C/C + C/T 146 (73)/166 (83) 1  
 T/T 54 (27)/34 (17) 1.77 (0.997–3.174) 0.05
Alleles
 C 195 (48.75)/247 (61.75) 1  
 T 205 (51.25)/153 (38.25) 1.67 (1.192–2.353) 0.003
p HWEa    0.15
IL-10 -1082A > G (rs1800896)
Codominant model   
 A/A 121 (60.5)/110 (55) 1  
 A/G 70 (35)/78 (39) 0.73 (0.447–1.205) 0.22
 G/G 9 (4.5)/12 (6) 0.89 (0.298–2.659) 0.83
Dominant model
 A/A 121 (60.5)/110 (55) 1  
 A/G + G/G 79 (39.5)/90 (45) 0.75 (0.466–1.210) 0.24
Recessive model
 A/A + A/G 191 (95.5)/188 (94) 1  
 G/G 9 (4.5)/12 (6) 1.004 (0.342–2.944) 0.99
Alleles
 A 312 (78)/298 (74.5) 1  
 G 88 (22)/102 (25.5) 0.83 (0.561–1.234) 0.36
p HWEa    0.7
TGFB1 -509C > T (rs1800469)
Codominant model   
 C/C 61 (30.5)/80 (40) 1  
 C/T 87 (43.5)/96 (48) 1.46 (0.854–2.514) 0.16
 T/T 52 (26)/24 (12) 3.73 (1.842–7.572) b 0.0001
Dominant model   
 C/C 61 (30.5)/80 (40) 1  
 C/T + T/T 139 (69.5)/120 (60) 1.91 (1.151–3.174) 0.01
Recessive model
 C/C + C/T 148 (74)/176 (88) 1  
 T/T 52 (26)/24 (12) 2.98 (1.593–5.597) 0.001
Alleles
 C 209 (52.25)/256 (64) 1  
 T 191 (47.75)/144 (36) 1.91 (1.354–2.701) 0.0001
p HWEa    0.55
TNFα -308G > A (rs 1800629)
Codominant model   
 G/G 164 (82)/161 (80.5) 1  
 G/A 26 (13)/36 (18) 0.55 (0.281–1.081) 0.08
 A/A 10 (5)/3 (1.5) 1.52 (0.305–7.631) 0.6
Dominant model   
 G/G 164 (82)/161 (80.5) 1  
 G/A + A/A 36 (18)/39 (19.5) 0.62 (0.332–1.187) 0.15
Recessive model  
 G/G + G/A 190 (95)/197 (98.5) 1  
 A/A 10 (5)/3 (1.5) 1.74 (0.356–8.519) 0.49
Alleles
 G 354 (88.5)/358 (89.5) 1  
 A 46 (11.50)/42 (10.5) 0.74 (0.421–1.305) 0.3
p HWEa    0.54
IFN-γ -1615C > T (rs2069705)
Codominant model   
 C/C 143 (71.5)/88 (44) 1  
 C/T 51 (25.1)/91 (45.5) 0.25 (0.149–0.445) 0.0001
 T/T 6 (3)/21 (10.5) 0.11 (0.038–0.351) b 0.0001
Dominant model   
 C/C 143 (71.5)/88 (44) 1  
 C/T + T/T 57 (28.5)/112 (56) 0.22 (0.135–0.385) 0.0001
Recessive model
 C/C + C/T 194 (97)/179 (89.5) 1  
 T/T 6 (3)/21 (10.5) 0.19 (0.068–0.581) 0.003
Alleles
 C 337 (84.25)/267 (66.75) 1  
 T 63 (15.75)/133 (33.25) 0.30 (0.203–0.468) 0.0001
p HWEa    0.72
  1. Bold text denotes significant p values (p < 0.006)
  2. *p < =0.006 Multiples comparisons adjustment by Bonferroni method
  3. aHardy-Weinberg Equilibrium in controls
  4. bStatistically significant p value for trend (p < 0.001)
  5. cOdds Ratio adjusted by age, CC history and smoking history
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BMC Cancer

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