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Table 1 Analysis of the reproductive and sexual life style conventional risk factors for cervical cancer in study population

From: Risk allelic load in Th2 and Th3 cytokines genes as biomarker of susceptibility to HPV-16 positive cervical cancer: a case control study

Sociodemographic characteristics

n (%) Controls/n (%) CC

ORc (95 % CI)

 

n = 200/200

Cervical cancer (CC)

p valuea

Age of menarche (years)

 

 <12

82 (41)/76 (38)

1 (reference)

 

 ≥12

118 (56)/124 (62)

0.76 (0.47–1.22)

0.26

Age at first intercourse (years)

 

 ≥18

114 (57)/50 (25)

1 (reference)

 

 <18

86 (43)/150 (75)

5.64 (3.32–9.56) b

0.0001

Parity

 

 ≤3

177 (88.5)/71 (35.5)

1 (reference)

 

 >3

23 (11.5)/129 (64.5)

7.41 (4.23–12.98) b

0.0001

Number of lifetime sexual partners

 

 <3

169 (84.5)/148 (74)

1 (reference)

 

 4 a 9

28 (14)/50 (25)

2.27 (1.24–4.15) b

0.008

 >10

3 (1.5)/2 (1)

2.79 (0.42–18.41)

0.28

Contraceptive method

 

 None

28 (14)/111 (55.5)

1 (reference)

 

 Non hormonals

88 (44)/56 (28)

0.25 (0.139–0.458)

0.0001

 Hormonal methods 6 months-5 years

84 (42)/33 (16.5)

0.15 (0.08–0.29) b

0.0001

History of previous STD

 

 None

109 (54.5)/144 (72)

1 (reference)

 

 Herpes

5 (2.5)/2 (1)

0.4 (0.065–2.44)

0.32

 Chlamydia

1 (0.5)/1 (0.5)

0.46 (0.028–7.50)

0.58

 Candidiasis

33 (16.5)/1 (0.5)

0.02 (0.003–0.235)

0.001

 Vaginosis

33 (16.5)/49 (24.5)

1.32 (0.73–2.39)

0.34

 HPV

19 (9.5)/3 (1.5)

0.18 (0.04–0.69)

0.01

Cancer family history

 

 No

176 (88)/158 (79)

1 (reference)

 

 Yes

24 (12)/42 (21)

2.19 (1.15–4.16) b

0.01

Smoking history

 

 No

155 (77.5)/125 (62.5)

1

 

 Yes

45 (22.5)/75 (37.5)

2.15 (1.28–3.63) b

0.004

  1. Bold text denotes significant p values (p < 0.05)
  2. a p value for Kruskal-Wallis test
  3. bStatistically significant p values for trend (p < 0.05)
  4. cOdds Ratio adjusted by age