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Table 5 IPA top canonical pathways

From: Protein expression changes induced in a malignant melanoma cell line by the curcumin analogue compound D6

  Ingenuity canonical pathways -log(B-H p-value) Molecules
1 Protein Ubiquitination Pathway 5,52E00 HSPB1,HSPA1L,DNAJB1,HSPH1,HSPA6,HSPE1,UBC
2 Aldosterone Signaling in Epithelial Cells 5,52E00 HSPB1,HSPA1L,DNAJB1,HSPH1,HSPA6,HSPE1
3 EIF2 Signaling 5,19E00 RPL17,RPL24,RPS27,RPS11,RPL26,RPS3
4 Huntington’s Disease Signaling 3,43E00 HSPA1L,DNAJB1,GNB2L1,HSPA6,UBC
5 Unfolded protein response 2,98E00 HSPA1L,HSPH1,HSPA6
6 14-3-3-mediated Signaling 2,06E00 TUBA1B,YWHAE,YWHAZ
7 Regulation of eIF4 and p70S6K Signaling 1,85E00 RPS27,RPS11,RPS3
8 Cell Cycle: G2/M DNA Damage Checkpoint Regulation 1,65E00 YWHAE,YWHAZ
9 mTOR Signaling 1,65E00 RPS27,RPS11,RPS3
10 Myc Mediated Apoptosis Signaling 1,59E00 YWHAE,YWHAZ
11 ERK5 Signaling 1,56E00 YWHAE,YWHAZ
  1. The table lists the canonical pathways identified by IPA as the most significantly involved in D6 biological effects (−logp-value ≤1.5 after multiple testing correction according to Benjamini Hochberg). Pathways found statistically significant also by the gene expression profile analysis (p value ≤0.001) are shown in bold characters [10]