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Table 4 IPA top bio functions and diseases

From: Protein expression changes induced in a malignant melanoma cell line by the curcumin analogue compound D6

 

Top bio functions and diseases

p-value

# molecules

1

Cellular Compromise

2.26E-06 - 4.58E-02

7

2

Cellular Function and Maintenance

2.26E-06 - 4.72E-02

8

3

Gene Expression

3.39E-06 - 2.74E-02

14

4

Protein Synthesis

4.88E-06 - 1.74E-02

10

5

Drug Metabolism

7.40E-05 - 3.31E-02

4

6

Small Molecule Biochemistry

7.40E-05 - 3.31E-02

8

7

Dermatological Diseases and Conditions

9.02E-05 - 8.75E-03

7

8

Cell Cycle

1.45E-04 - 3.88E-02

6

9

Neurological Disease

1.49E-04 - 1.61E-02

10

10

Post-Translational Modification

3.36E-04 - 3.74E-02

6

11

Protein Folding

3.36E-04 - 3.48E-02

3

12

Cell Morphology

5.78E-04 - 4.30E-02

9

13

Cellular Assembly and Organization

5.78E-04 - 4.58E-02

8

14

Cell Death and Survival

8.34E-04 - 4.86E-02

13

15

Psychological Disorders

8.35E-04 - 3.14E-02

6

16

Skeletal and Muscular Disorders

8.35E-04 - 4.18E-02

12

17

Cellular Development

1.31E-03 - 3.45E-02

6

18

Skeletal and Muscular System Development and Function

1.31E-03 - 1.02E-02

4

19

Tissue Development

1.31E-03 - 4.72E-02

7

20

Cancer

1.46E-03 - 5.00E-02

19

21

Cardiovascular Disease

1.46E-03 - 2.61E-02

5

22

DNA Replication, Recombination, and Repair

1.46E-03 - 4.86E-02

6

23

Developmental Disorder

1.46E-03 - 2.89E-02

7

24

Embryonic Development

1.46E-03 - 3.60E-02

5

25

Hematological Disease

1.46E-03 - 4.16E-02

9

26

Hereditary Disorder

1.46E-03 - 2.89E-02

6

27

Immunological Disease

1.46E-03 - 4.18E-02

12

28

Nervous System Development and Function

1.46E-03 - 4.86E-02

4

29

Organ Morphology

1.46E-03 - 4.16E-02

4

30

Organismal Development

1.46E-03 - 4.16E-02

4

31

Organismal Injury and Abnormalities

1.46E-03 - 5.00E-02

21

32

Respiratory Disease

1.46E-03 - 4.58E-02

5

33

Tissue Morphology

1.46E-03 - 4.72E-02

4

34

Reproductive System Disease

1.68E-03 - 5.00E-02

11

35

RNA Post-Transcriptional Modification

1.77E-03 - 2.78E-02

4

  1. The table lists the biological functions and diseases identified by IPA as the most significantly influenced by D6 activity (p value ≤0.005, >2 identified molecules). p-values are reported as range of values referred to the several sub-groups classified by IPA into each bio-functions and disease major group. Bio-functions and diseases found statistically significant also by the gene expression profile analysis (p value ≤0.001) are shown in bold characters [10]