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Table 4 IPA top bio functions and diseases

From: Protein expression changes induced in a malignant melanoma cell line by the curcumin analogue compound D6

  Top bio functions and diseases p-value # molecules
1 Cellular Compromise 2.26E-06 - 4.58E-02 7
2 Cellular Function and Maintenance 2.26E-06 - 4.72E-02 8
3 Gene Expression 3.39E-06 - 2.74E-02 14
4 Protein Synthesis 4.88E-06 - 1.74E-02 10
5 Drug Metabolism 7.40E-05 - 3.31E-02 4
6 Small Molecule Biochemistry 7.40E-05 - 3.31E-02 8
7 Dermatological Diseases and Conditions 9.02E-05 - 8.75E-03 7
8 Cell Cycle 1.45E-04 - 3.88E-02 6
9 Neurological Disease 1.49E-04 - 1.61E-02 10
10 Post-Translational Modification 3.36E-04 - 3.74E-02 6
11 Protein Folding 3.36E-04 - 3.48E-02 3
12 Cell Morphology 5.78E-04 - 4.30E-02 9
13 Cellular Assembly and Organization 5.78E-04 - 4.58E-02 8
14 Cell Death and Survival 8.34E-04 - 4.86E-02 13
15 Psychological Disorders 8.35E-04 - 3.14E-02 6
16 Skeletal and Muscular Disorders 8.35E-04 - 4.18E-02 12
17 Cellular Development 1.31E-03 - 3.45E-02 6
18 Skeletal and Muscular System Development and Function 1.31E-03 - 1.02E-02 4
19 Tissue Development 1.31E-03 - 4.72E-02 7
20 Cancer 1.46E-03 - 5.00E-02 19
21 Cardiovascular Disease 1.46E-03 - 2.61E-02 5
22 DNA Replication, Recombination, and Repair 1.46E-03 - 4.86E-02 6
23 Developmental Disorder 1.46E-03 - 2.89E-02 7
24 Embryonic Development 1.46E-03 - 3.60E-02 5
25 Hematological Disease 1.46E-03 - 4.16E-02 9
26 Hereditary Disorder 1.46E-03 - 2.89E-02 6
27 Immunological Disease 1.46E-03 - 4.18E-02 12
28 Nervous System Development and Function 1.46E-03 - 4.86E-02 4
29 Organ Morphology 1.46E-03 - 4.16E-02 4
30 Organismal Development 1.46E-03 - 4.16E-02 4
31 Organismal Injury and Abnormalities 1.46E-03 - 5.00E-02 21
32 Respiratory Disease 1.46E-03 - 4.58E-02 5
33 Tissue Morphology 1.46E-03 - 4.72E-02 4
34 Reproductive System Disease 1.68E-03 - 5.00E-02 11
35 RNA Post-Transcriptional Modification 1.77E-03 - 2.78E-02 4
  1. The table lists the biological functions and diseases identified by IPA as the most significantly influenced by D6 activity (p value ≤0.005, >2 identified molecules). p-values are reported as range of values referred to the several sub-groups classified by IPA into each bio-functions and disease major group. Bio-functions and diseases found statistically significant also by the gene expression profile analysis (p value ≤0.001) are shown in bold characters [10]