An uncommon manifestation of paraneoplastic cerebellar degeneration in a patient with high grade urothelial, carcinoma with squamous differentiation: A case report and literature review

Table 3 Clinical and Pathological Features in Nine Cases of Bladder Cancer with PNS

Case No.	Author	Year	Age/Gender	Stage	Pathology	Clinical syndromes	Antibody	Treatment	Prognosis
1	Gita et al.[17]	2015	73/F	M^a	Poorly differentiated carcinoma with squamous features	PEM	Negtive	Surgical resection and immunosuppression	Partial improvement
2	Syuichi et al.[12]	2013	66/M	N/A	Urothelial carcinoma	PCD	Anti-CKB	TURBT	No improvement
3	Lukacs et al.[20]	2012	76/F	pTa	Urothelial carcinoma	PEM and SSN	Anti-Hu	TURBT	Partial improvement
4	Forte et al.[21]	2009	76/M	pT2	High grade urothelial carcinoma	Neuromyotonia	Anti-VGKC	Resectionofthetumour	Complete improvement
5	Sean et al.[14]	2003	59/M	N/A	N/A	POM	Anti-Ri	N/A	N/A
6	Charles et al.[22]	2001	57/M	pT3	High grade urothelial carcinoma	POM	Anti-Ri	Radical cystectomy and immunosuppression	Partial improvement
7	Lowe et al.[23]	1992	71/M	pT3	High grade urothelial carcinoma	Visual changes, glossal spasm and dysphagia	N/A	Combination chemotherapy	Complete improvement
8	John et al.[11]	1999	64/F	pT2	High grade urothelial carcinoma	PCD	Anti-Yo	Partial resection of the bladder	No improvement
9	Current report	2015	68/M	pCIS	High grade urothelial carcinoma and the well-differentiated squamous cell carcinoma	PCD	Negtive	Laparoscopic radical cystectomy	Complete improvement

^aA recurrent pelvis mass proven as urothelial carcinoma 22 years after radical cystectomy; PEM Paraneoplastic encephalomyelitis; PCD Paraneoplastic cerebellar degeneration; SSN Subacute sensory neuronopathy; POM Paraneoplastic opsoclonus-myoclonus; Anti-CKB anti-creatine kinase, brain-type; N/A Not available

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