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Fig. 1 | BMC Cancer

Fig. 1

From: The non-genomic loss of function of tumor suppressors: an essential role in the pathogenesis of chronic myeloid leukemia chronic phase

Fig. 1

Tumor suppressors network associated with the BCR-ABL/PI3K/AKT pathway. Schematic representation of the BCR-ABL/PI3K/AKT pathway and the role of PTEN and FOXO tumor suppressors. This carton highlights how BCR-ABL inactivates PTEN through CKII-mediated phosphorylation and HAUSP-mediated changes of cellular compartmentalization. Furthermore, BCR-ABL promotes FOXO inactivation through the regulation of its cellular localization. We also speculate on the putative regulation of FOXO localization through HAUSP in CML, although BCR-ABL/HAUSP/FOXO connection has to be demonstrated

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