Table 1 Basic characteristics
From: Evaluation of clinical parameters influencing the development of bone metastasis in breast cancer
patients with advanced breast cancer | bone-only metastases | p-value | |||
|---|---|---|---|---|---|
Total | yes | no | |||
886 | 226 (25.5 %) | 660 (74.5 %) | |||
Age at primary diagnosis (in years) | mean: 61 (SD 14.2) (median:62) | mean: 65 (SD 14.3) (median:67) | mean: 60 (SD 13.9) (median: 61) | 0.03 | |
Range: 22–96 | Range: 30–93 | Range:22–96 | |||
Metastatic free survival (MFS) (in months) | mean: 25 (SD 27.7) (median:18) | mean: 23 (SD 33.3) (median:13) | mean: 26 (SD 25.4) (median: 19) | 0.03 | |
Range: 0–197 | Range: 0–197 | Range:0–142 | |||
T-categories (in absolut numbers (percent) | T1 | 283 (31.9) | 72 (25.4) | 211 (74.6) | 0.385 |
T2 | 485 (54.7) | 118 (24.3) | 367 (75.7) | ||
T3/T4 | 118 (13.3) | 36 (30.5) | 82 (69.5) | ||
Menopausal status (dto.) | premenopausal | 204 (23.0) | 37 (18.1) | 167 (81.9) | 0.026 |
perimenopausal | 31 (3.5) | 6 (19.4) | 25 (80.6) | ||
postmenopausal | 649 (73.3) | 182 (28.0) | 467 (72.0) | ||
unknown | 2 (0.2) | 1 (50.0) | 1 (50.0) | ||
Receptor staus (dto.) | negative | 210 (23.7) | 24 (11.4) | 186 (88.6) | <0.001 |
positive or unknown | 676 (76.3) | 202 (29.9) | 474 (70.1) | ||
HER2/neu (dto.) | negative or unknown | 704 (79.5) | 190 (27.0) | 514 (73.0) | 0.047 |
positive | 182 (20.5) | 36 (19.8) | 146 (80.2) | ||
Grading (dto.) | 1 | 26 (2.9) | 8 (30.8) | 18 (69.2) | 0.002 |
2 | 416 (47.0) | 127 (30.5) | 289 (69.5) | ||
3 | 444 (50.1) | 91 (20.5) | 353 (79.5) | ||
Nodal staus (dto.) | nodal negative | 268 | 63 (23.5) | 205 (76.5) | 0.716 |
1 < = N < = 3 | 198 | 49 (24.7) | 149 (75.3) | ||
3 < N < =10 | 198 | 49 (24.7) | 149 (75.3) | ||
N > 10 | 193 | 51 (26.4) | 142 (73.6) | ||
sub-categories (dto.) | luminal A | 352 (39.7) | 115 (32.7) | 237 (67.3) | <0.001 |
luminal B/HER2- | 221 (24.9) | 62 (28.1) | 159 (71.9) | ||
luminal B/HER2+ | 103 (11.6) | 25 (24.3) | 78 (75.7) | ||
TNBC | 131 (14.8) | 13 (9.9) | 118 (90.1) | ||
HER2-overexpressing | 79 (8.9) | 11 (13.9) | 68 (86.1) | ||