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Fig. 2 | BMC Cancer

Fig. 2

From: Heme oxygenase is not involved in the anti-proliferative effects of statins on pancreatic cancer cells

Fig. 2

The effect of statins on activity and expression of HMOX in pancreatic cancer cells a) HMOX activity was measured in PA-TU-8902, MiaPaCa-2 and BxPC-3 pancreatic cancer cell lines after 12 h of statin treatment (12 μM). b HMOX activity after 12 h of treatment were measured in PA-TU-8902, and c) HMOX1 mRNA after 4 h of treatment. Hemin (30 μM) and PGJ2 (5 μM) served as positive controls for HMOX1 induction ability. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001 vs. control cells CON, control cells; SIM, simvastatin; CER, cerivastatin; FLU, fluvastatin; LOV, lovastatin; PRA, pravastatin; PGJ2, 15-deoxy-Δ-12,14-prostaglandin J2

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BMC Cancer

ISSN: 1471-2407

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