Fig. 2

Alteration of CXCR4 protein expression in PaCa cells by GEM. PaCa cells were treated with different concentrations of GEM (0–20 μM) for 72 h. The concentrations of CXCR4 protein in a MIA PaCa-2 GEM-S, b MIA PaCa-2 GEM-R, c AsPC-1 GEM-S d and AsPC-1 GEM-R were measured by ELISA. Values are expressed as means ± SDs. Multiple comparisons were performed by using one-way ANOVA followed by Dunnett’s test. **, P < 0.01; *, P < 0.05 versus control (0 μM)