TY - JOUR AU - Siegel, R. AU - Naishadham, D. AU - Jemal, A. PY - 2013 DA - 2013// TI - Cancer statistics, 2013 JO - CA Cancer J Clin VL - 63 UR - https://doi.org/10.3322/caac.21166 DO - 10.3322/caac.21166 ID - Siegel2013 ER - TY - JOUR AU - Hidalgo, M. PY - 2010 DA - 2010// TI - Pancreatic cancer JO - N Engl J Med VL - 362 UR - https://doi.org/10.1056/NEJMra0901557 DO - 10.1056/NEJMra0901557 ID - Hidalgo2010 ER - TY - JOUR AU - Burris, H. A. AU - Moore, M. J. AU - Andersen, J. AU - Green, M. R. AU - Rothenberg, M. L. AU - Modiano, M. R. PY - 1997 DA - 1997// TI - Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer: a randomized trial JO - J Clin Oncol VL - 15 ID - Burris1997 ER - TY - JOUR AU - Wong, H. H. AU - Lemoine, N. R. PY - 2009 DA - 2009// TI - Pancreatic cancer: molecular pathogenesis and new therapeutic targets JO - Nat Rev Gastroenterol Hepatol VL - 6 UR - https://doi.org/10.1038/nrgastro.2009.89 DO - 10.1038/nrgastro.2009.89 ID - Wong2009 ER - TY - JOUR AU - Matsuo, Y. AU - Ochi, N. AU - Sawai, H. AU - Yasuda, A. AU - Takahashi, H. AU - Funahashi, H. PY - 2009 DA - 2009// TI - CXCL8/IL-8 and CXCL12/SDF-1alpha co-operatively promote invasiveness and angiogenesis in pancreatic cancer JO - Int J Cancer VL - 124 UR - https://doi.org/10.1002/ijc.24040 DO - 10.1002/ijc.24040 ID - Matsuo2009 ER - TY - JOUR AU - Murphy, P. M. PY - 2001 DA - 2001// TI - Chemokines and the molecular basis of cancer metastasis JO - N Engl J Med VL - 345 UR - https://doi.org/10.1056/NEJM200109133451113 DO - 10.1056/NEJM200109133451113 ID - Murphy2001 ER - TY - JOUR AU - Balkwill, F. PY - 2004 DA - 2004// TI - The significance of cancer cell expression of the chemokine receptor CXCR4 JO - Semin Cancer Biol VL - 14 UR - https://doi.org/10.1016/j.semcancer.2003.10.003 DO - 10.1016/j.semcancer.2003.10.003 ID - Balkwill2004 ER - TY - JOUR AU - Homey, B. AU - Müller, A. AU - Zlotnik, A. PY - 2002 DA - 2002// TI - Chemokines: agents for the immunotherapy of cancer? JO - Nat Rev Immunol VL - 2 UR - https://doi.org/10.1038/nri748 DO - 10.1038/nri748 ID - Homey2002 ER - TY - JOUR AU - Kulbe, H. AU - Levinson, N. R. AU - Balkwill, F. AU - Wilson, J. L. PY - 2004 DA - 2004// TI - The chemokine network in cancer-much more than directing cell movement JO - Int J Dev Biol VL - 48 UR - https://doi.org/10.1387/ijdb.041814hk DO - 10.1387/ijdb.041814hk ID - Kulbe2004 ER - TY - JOUR AU - Burger, J. A. AU - Kipps, T. J. PY - 2006 DA - 2006// TI - CXCR4: a key receptor in the crosstalk between tumor cells and their microenvironment JO - Blood VL - 107 UR - https://doi.org/10.1182/blood-2005-08-3182 DO - 10.1182/blood-2005-08-3182 ID - Burger2006 ER - TY - JOUR AU - Strieter, R. M. PY - 2001 DA - 2001// TI - Chemokines: not just leukocyte chemoattractants in the promotion of cancer JO - Nat Immunol VL - 2 UR - https://doi.org/10.1038/86286 DO - 10.1038/86286 ID - Strieter2001 ER - TY - JOUR AU - Hall, J. M. AU - Korach, K. S. PY - 2003 DA - 2003// TI - Stromal cell-derived factor 1, a novel target of estrogen receptor action, mediates the mitogenic effects of estradiol in ovarian and breast cancer cells JO - Mol Endocrinol VL - 17 UR - https://doi.org/10.1210/me.2002-0438 DO - 10.1210/me.2002-0438 ID - Hall2003 ER - TY - JOUR AU - Barbero, S. AU - Bonavia, R. AU - Bajetto, A. AU - Porcile, C. AU - Pirani, P. AU - Ravetti, J. L. PY - 2003 DA - 2003// TI - Stromal cell-derived factor 1alpha stimulates human glioblastoma cell growth through the activation of both extracellular signal-regulated kinases 1/2 and Akt JO - Cancer Res VL - 63 ID - Barbero2003 ER - TY - JOUR AU - Muller, A. AU - Homey, B. AU - Soto, H. AU - Ge, N. AU - Catron, D. AU - Buchanan, M. E. PY - 2001 DA - 2001// TI - Involvement of chemokine receptors in breast cancer metastasis JO - Nature VL - 410 UR - https://doi.org/10.1038/35065016 DO - 10.1038/35065016 ID - Muller2001 ER - TY - JOUR AU - Koshiba, T. AU - Hosotani, R. AU - Miyamoto, Y. AU - Ida, J. AU - Tsuji, S. AU - Nakajima, S. PY - 2000 DA - 2000// TI - Expression of stromal cell-derived factor 1 and CXCR4 ligand receptor system in pancreatic cancer: a possible role for tumor progression JO - Clin Cancer Res VL - 6 ID - Koshiba2000 ER - TY - JOUR AU - Sun, Y. X. AU - Wang, J. AU - Shelburne, C. E. PY - 2003 DA - 2003// TI - Expression of CXCR4 and CXCL12 (SDF-1) in human prostate cancers (P Ca) in vivo JO - J Cell Biochem VL - 89 UR - https://doi.org/10.1002/jcb.10522 DO - 10.1002/jcb.10522 ID - Sun2003 ER - TY - JOUR AU - Singh, S. AU - Srivastava, S. K. AU - Bhardwaj, A. AU - Owen, L. B. AU - Singh, A. P. PY - 2010 DA - 2010// TI - CXCL12-CXCR4 signalling axis confers gemcitabine resistance to pancreatic cancer cells: a novel target for therapy JO - Br J Cancer VL - 103 UR - https://doi.org/10.1038/sj.bjc.6605968 DO - 10.1038/sj.bjc.6605968 ID - Singh2010 ER - TY - JOUR AU - Clercq, E. PY - 2003 DA - 2003// TI - The bicyclam AMD3100 story JO - Nat Rev Drug Discov VL - 2 UR - https://doi.org/10.1038/nrd1134 DO - 10.1038/nrd1134 ID - Clercq2003 ER - TY - JOUR AU - Skerlj, R. T. AU - Bridger, G. J. AU - Kaller, A. AU - McEachern, E. J. AU - Crawford, J. B. AU - Zhou, Y. PY - 2010 DA - 2010// TI - Discovery of novel small molecule orally bioavailable C-X-C chemokine receptor 4 antagonists that are potent inhibitors of T-tropic (X4) HIV-1 replication JO - J Med Chem VL - 53 UR - https://doi.org/10.1021/jm100073m DO - 10.1021/jm100073m ID - Skerlj2010 ER - TY - JOUR AU - Murakami, T. AU - Kumakura, S. AU - Yamazaki, T. AU - Tanaka, R. AU - Hamatake, M. AU - Okuma, K. PY - 2009 DA - 2009// TI - The novel CXCR4 antagonist KRH-3955 is an orally bioavailable and extremely potent inhibitor of human immunodeficiency virus type 1 infection: comparative studies with AMD3100 JO - Antimicrob Agents Chemother VL - 53 UR - https://doi.org/10.1128/AAC.01727-08 DO - 10.1128/AAC.01727-08 ID - Murakami2009 ER - TY - JOUR AU - Cabioglu, N. AU - Summy, J. AU - Miller, C. AU - Parikh, N. U. AU - Sahin, A. A. AU - Tuzlali, S. PY - 2005 DA - 2005// TI - CXCL12/stromal cell-derived factor-1alpha transactivates HER2-neu in breast cancer cells by a novel pathway involving Src kinase activation JO - Cancer Res VL - 65 UR - https://doi.org/10.1158/0008-5472.CAN-04-1303 DO - 10.1158/0008-5472.CAN-04-1303 ID - Cabioglu2005 ER - TY - JOUR AU - Hartmann, T. N. AU - Burger, J. A. AU - Glodek, A. AU - Fujii, N. AU - Burger, M. PY - 2005 DA - 2005// TI - CXCR4 chemokine receptor and integrin signaling co-operate in mediating adhesion and chemoresistance in small cell lung cancer (SCLC) cells JO - Oncogene VL - 24 UR - https://doi.org/10.1038/sj.onc.1208621 DO - 10.1038/sj.onc.1208621 ID - Hartmann2005 ER - TY - JOUR AU - Ohira, S. AU - Sasaki, M. AU - Harada, K. AU - Sato, Y. AU - Zen, Y. AU - Isse, K. PY - 2006 DA - 2006// TI - Possible regulation of migration of intrahepatic cholangiocarcinoma cells by interaction of CXCR4 expressed in carcinoma cells with tumor necrosis factor-alpha and stromal-derived factor-1 released in stroma JO - Am J Pathol VL - 168 UR - https://doi.org/10.2353/ajpath.2006.050204 DO - 10.2353/ajpath.2006.050204 ID - Ohira2006 ER - TY - JOUR AU - Yasumoto, K. AU - Koizumi, K. AU - Kawashima, A. AU - Saitoh, Y. AU - Arita, Y. AU - Shinohara, K. PY - 2006 DA - 2006// TI - Role of the CXCL12/CXCR4 axis in peritoneal carcinomatosis of gastric cancer JO - Cancer Res VL - 66 UR - https://doi.org/10.1158/0008-5472.CAN-05-3393 DO - 10.1158/0008-5472.CAN-05-3393 ID - Yasumoto2006 ER - TY - JOUR AU - Marchesi, F. AU - Monti, P. AU - Leone, B. E. AU - Zerbi, A. AU - Vecchi, A. AU - Piemonti, L. PY - 2004 DA - 2004// TI - Increased survival, proliferation, and migration in metastatic human pancreatic tumor cells expressing functional CXCR4 JO - Cancer Res VL - 64 UR - https://doi.org/10.1158/0008-5472.CAN-04-1343 DO - 10.1158/0008-5472.CAN-04-1343 ID - Marchesi2004 ER - TY - JOUR AU - Saur, D. AU - Seidler, B. AU - Schneider, G. AU - Algül, H. AU - Beck, R. PY - 2005 DA - 2005// TI - CXCR4 expression increases liver and lung metastasis in a mouse model of pancreatic cancer JO - Gastroenterology VL - 129 UR - https://doi.org/10.1053/j.gastro.2005.06.056 DO - 10.1053/j.gastro.2005.06.056 ID - Saur2005 ER - TY - JOUR AU - Zhang, H. AU - Zhang, L. AU - Chen, L. AU - Li, W. AU - Li, F. AU - Chen, Q. PY - 2014 DA - 2014// TI - Stromal cell-derived factor-1 and its receptor CXCR4 are upregulated expression indegenerated intervertebral discs JO - Int J Med Sci VL - 11 UR - https://doi.org/10.7150/ijms.7489 DO - 10.7150/ijms.7489 ID - Zhang2014 ER - TY - JOUR AU - Banerjee, S. AU - Wang, Z. AU - Kong, D. AU - Sarkar, F. H. PY - 2009 DA - 2009// TI - 3,3′-Diindolylmethane enhances chemosensitivity of multiple chemotherapeutic agents in pancreatic cancer JO - Cancer Res VL - 69 UR - https://doi.org/10.1158/0008-5472.CAN-09-0838 DO - 10.1158/0008-5472.CAN-09-0838 ID - Banerjee2009 ER - TY - JOUR AU - Ng, S. S. W. AU - Tsao, M. S. AU - Chow, S. AU - Hedley, D. W. PY - 2000 DA - 2000// TI - Inhibition of phosphatidylinositide 3-kinase enhances gemcitabine-induced apoptosis in human pancreatic cancer cells JO - Cancer Res VL - 60 ID - Ng2000 ER - TY - JOUR AU - Ellenrieder, V. AU - Hendler, S. F. AU - Boeck, W. AU - Seufferlein, T. AU - Menke, A. AU - Ruhland, C. PY - 2001 DA - 2001// TI - Transforming growth factor beta1 treatment leads to an epithelial-mesenchymal transdifferentiation of pancreatic cancer cells requiring extracellular signal-regulated kinase 2 activation JO - Cancer Res VL - 61 ID - Ellenrieder2001 ER - TY - JOUR AU - Hwang, R. F. AU - Moore, T. AU - Arumugam, T. AU - Ramachandran, V. AU - Amos, K. D. AU - Rivera, A. PY - 2008 DA - 2008// TI - Cancer-associated stromal fibroblasts promote pancreatic tumor progression JO - Cancer Res VL - 68 UR - https://doi.org/10.1158/0008-5472.CAN-07-5714 DO - 10.1158/0008-5472.CAN-07-5714 ID - Hwang2008 ER - TY - JOUR AU - Hermann, P. C. AU - Huber, S. L. AU - Herrler, T. AU - Aicher, A. AU - Ellwart, J. W. AU - Guba, M. PY - 2007 DA - 2007// TI - Distinct populations of cancer stem cells determine tumor growth and metastatic activity in human pancreatic cancer JO - Cell Stem Cell VL - 1 UR - https://doi.org/10.1016/j.stem.2007.06.002 DO - 10.1016/j.stem.2007.06.002 ID - Hermann2007 ER - TY - JOUR AU - Singh, S. AU - Sadanandam, A. AU - Singh, R. K. PY - 2007 DA - 2007// TI - Chemokines in tumor angiogenesis and metastasis JO - Cancer Cancer Metastasis Rev VL - 26 UR - https://doi.org/10.1007/s10555-007-9068-9 DO - 10.1007/s10555-007-9068-9 ID - Singh2007 ER - TY - JOUR AU - Maréchal, R. AU - Demetter, P. AU - Nagy, N. AU - Berton, A. AU - Decaestecker, C. AU - Polus, M. PY - 2009 DA - 2009// TI - High expression of CXCR4 may predict poor survival in resected pancreatic adenocarcinoma JO - Br J Cancer VL - 100 UR - https://doi.org/10.1038/sj.bjc.6605020 DO - 10.1038/sj.bjc.6605020 ID - Maréchal2009 ER - TY - JOUR AU - Wu, P. F. AU - Lu, Z. P. AU - Cai, B. B. AU - Tian, L. AU - Zou, C. AU - Jiang, K. R. PY - 2013 DA - 2013// TI - Role of CXCL12/CXCR4 signaling axis in pancreatic cancer JO - Chin Med J (Engl) VL - 126 ID - Wu2013 ER - TY - JOUR AU - Katsumoto, K. AU - Kume, S. PY - 2013 DA - 2013// TI - The role of CXCL12-CXCR4 signaling pathway in pancreatic development JO - Theranostics VL - 3 UR - https://doi.org/10.7150/thno.4806 DO - 10.7150/thno.4806 ID - Katsumoto2013 ER - TY - JOUR AU - Mori, T. AU - Doi, R. AU - Koizumi, M. AU - Toyoda, E. AU - Ito, D. AU - Kami, K. PY - 2004 DA - 2004// TI - CXCR4 antagonist inhibits stromal cell-derived factor 1-induced migration and invasion of human pancreatic cancer JO - Mol Cancer Ther VL - 3 ID - Mori2004 ER - TY - JOUR AU - Teicher, B. A. AU - Fricker, S. P. PY - 2010 DA - 2010// TI - CXCL12 (SDF-1)/CXCR4 pathway in cancer JO - Clin Cancer Res VL - 16 UR - https://doi.org/10.1158/1078-0432.CCR-09-2329 DO - 10.1158/1078-0432.CCR-09-2329 ID - Teicher2010 ER - TY - JOUR AU - Hendrix, C. W. AU - Flexner, C. AU - MacFarland, R. T. AU - Giandomenico, C. AU - Fuchs, E. J. AU - Redpath, E. PY - 2000 DA - 2000// TI - Pharmacokinetics and safety of AMD-3100, a novel antagonist of the CXCR4 chemokine receptor, in human volunteers JO - Antimicrob Agents Chemother VL - 44 UR - https://doi.org/10.1128/AAC.44.6.1667-1673.2000 DO - 10.1128/AAC.44.6.1667-1673.2000 ID - Hendrix2000 ER - TY - JOUR AU - Hendrix, C. W. AU - Collier, A. C. AU - Lederman, M. M. AU - Schols, D. AU - Pollard, R. B. AU - Brown, S. PY - 2004 DA - 2004// TI - Safety, pharmacokinetics, and antiviral activity of AMD3100, a selective CXCR4 receptor inhibitor, in HIV-1 infection JO - J Acquir Immune Defic Syndr VL - 37 UR - https://doi.org/10.1097/01.qai.0000137371.80695.ef DO - 10.1097/01.qai.0000137371.80695.ef ID - Hendrix2004 ER - TY - JOUR AU - Scozzafava, A. AU - Mastrolorenzo, A. AU - Supuran, C. T. PY - 2002 DA - 2002// TI - Non-peptidic chemokine receptors antagonists as emerging anti-HIV agents JO - J Enzyme Inhib Med Chem VL - 17 UR - https://doi.org/10.1080/14756360290024227 DO - 10.1080/14756360290024227 ID - Scozzafava2002 ER - TY - JOUR AU - Mosi, R. M. AU - Anastassova, V. AU - Cox, J. AU - Darkes, M. C. AU - Idzan, S. R. AU - Labrecque, J. PY - 2012 DA - 2012// TI - The molecular pharmacology of AMD11070: an orally bioavailable CXCR4 HIV entryinhibitor JO - Biochem Pharmacol VL - 83 UR - https://doi.org/10.1016/j.bcp.2011.11.020 DO - 10.1016/j.bcp.2011.11.020 ID - Mosi2012 ER - TY - JOUR AU - Parameswaran, R. AU - Yu, M. AU - Lim, M. AU - Groffen, J. AU - Heisterkamp, N. PY - 2011 DA - 2011// TI - Combination of drug therapy in acute lymphoblastic leukemia with a CXCR4 antagonist JO - Leukemia VL - 25 UR - https://doi.org/10.1038/leu.2011.76 DO - 10.1038/leu.2011.76 ID - Parameswaran2011 ER - TY - JOUR AU - O’Boyle, G. AU - Swidenbank, I. AU - Marshall, H. AU - Barker, C. E. AU - Armstrong, J. AU - White, S. A. PY - 2013 DA - 2013// TI - Inhibition of CXCR4-CXCL12 chemotaxis in melanoma by AMD11070 JO - Br J Cancer VL - 108 UR - https://doi.org/10.1038/bjc.2013.124 DO - 10.1038/bjc.2013.124 ID - O’Boyle2013 ER - TY - JOUR AU - Arora, S. AU - Bhardwaj, A. AU - Singh, S. AU - Srivastava, S. K. AU - McClellan, S. AU - Nirodi, C. S. PY - 2013 DA - 2013// TI - An undesired effect of chemotherapy: gemcitabine promotes pancreatic cancer cell invasiveness through reactive oxygen species-dependent, nuclear factor κB- and hypoxia-inducible factor 1α-mediated up-regulation of CXCR4 JO - J Biol Chem VL - 288 UR - https://doi.org/10.1074/jbc.M113.484576 DO - 10.1074/jbc.M113.484576 ID - Arora2013 ER - TY - JOUR AU - Guo, F. AU - Wang, Y. AU - Liu, J. AU - Mok, S. C. AU - Xue, F. AU - Zhang, W. PY - 2015 DA - 2015// TI - CXCL12/CXCR4: a symbiotic bridge linking cancer cells and their stromal neighbors in oncogenic commnucation networks JO - Oncogene ID - Guo2015 ER -