Fig. 1
From: Combinatory effect of BRCA1 and HERC2 expression on outcome in advanced non-small-cell lung cancer
The protein BRCA1 is recruited at DNA damage through a recognition mechanism implying the phosphorylation of histone H2AX and leading to the assembly of a protein complex that induces histones post-translational modification called ubiquitination. This protein complex includes the RING finger ubiquitin ligase 8 (RNF8), the conjugating enzyme 13 (UBC13) and the E3 ubiquiting ligase HECT domain-containing protein 2 (HERC2). The biological model of BRCA1 recruitment at DNA damage sites was used to select the genes to evaluate as potential predictive markers of platinum sensitivity in lung cancer