Table 1 Inclusion and exclusion criteria
| Inclusion criteria | Exclusion criteria |
|---|---|
| 1. Histologically confirmed organ-confined unilateral PCa on TTMB (clinical stage T1c-T2b) |
1. Bleeding disorder (prothrombin time > 14.5 s., partial thromboplastin time > 34 s.), Platelet Count <140/uL, 2. No ability to stop anticoagulant or antiplatelet therapy |
| 2. Gleason sum score 6 or 7 |
3. Active (urinary tract) infection 4. History of bladder neck contracture 5. Major concurrent debilitating illness or ASA ≥4 6. Cardiac History |
| 3. PSA <15 ng/mL or PSA >15 ng/mL counselled with caution |
7. Inflammatory bowel disease 8. Major rectal surgery 9. Previous radiation to pelvis 10. Prior or concurrent malignancy |
| 4. Life expectancy of >10 years, age ≥18 years |
11. Biologic or chemotherapy for PCa 12. Hormonal therapy within last 6 months 13. Any resection or stenting of the prostate 14. Prostate calcification >5 mm |
