Table 1 Inclusion and exclusion criteria

1. Histologically confirmed organ-confined unilateral PCa on TTMB (clinical stage T1c-T2b)

1. Bleeding disorder (prothrombin time > 14.5 s., partial thromboplastin time > 34 s.), Platelet Count <140/uL,

2. No ability to stop anticoagulant or antiplatelet therapy

2. Gleason sum score 6 or 7

3. Active (urinary tract) infection

4. History of bladder neck contracture

5. Major concurrent debilitating illness or ASA ≥4

6. Cardiac History

3. PSA <15 ng/mL or PSA >15 ng/mL counselled with caution

7. Inflammatory bowel disease

8. Major rectal surgery

9. Previous radiation to pelvis

10. Prior or concurrent malignancy

4. Life expectancy of >10 years, age ≥18 years

11. Biologic or chemotherapy for PCa

12. Hormonal therapy within last 6 months

13. Any resection or stenting of the prostate

14. Prostate calcification >5 mm