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Table 4 Cox proportional hazards model univariate and multivariate analyses of individual parameters for correlations with overall survival (342 cases)

From: MEK5 overexpression is associated with the occurrence and development of colorectal cancer

 

Univariate analysis

Multivariate analysis

 

All cases

Mean survival (months)

P value

HR (95 % CI)

P value

Sex

  

0.988

  

 Female

157

94.2

   

 Male

185

91.7

   

Age at diagnosis (years)

  

0.144

  

  < 60

159

94.9

   

  ≥ 60

183

90.6

   

Tumor location

  

0.023

1.76(1.17–2.67)

0.008

 Rectum

160

96.5

   

 Colon

182

88.8

   

TNM stage

  

0.000

2.75(1.82–4.16)

0.000

 I-II

195

106.1

   

 III-IV

147

73.0

   

Differentiation grade

  

0.001

2.40(1.34–4.28)

0.003

 Well and Moderate

312

96.5

   

 Poorly

30

60.9

   

Serosal invasion

  

0.411

  

 Yes

73

95.8

   

 No

269

93.1

   

MEK5 expression

  

0.012

1.51(1.01–2.25)

0.045

 Normal expression

233

95.2

   

 Over expression

109

84.8