Table 3 Cox proportional hazards model univariate and multivariate analyses of individual parameters for correlations with disease-free survival (342 cases)
From: MEK5 overexpression is associated with the occurrence and development of colorectal cancer
Univariate analysis | Multivariate analysis | ||||
|---|---|---|---|---|---|
All cases | Mean survival (months) | P value | HR (95 % CI) | P value | |
Sex | 0.938 | ||||
Female | 157 | 93.5 | |||
Male | 185 | 92.9 | |||
Age at diagnosis (years) | 0.754 | ||||
< 60 | 159 | 91.0 | |||
≥ 60 | 183 | 94.7 | |||
Tumor location | 0.011 | 1.850 (1.23–2.78) | 0.003 | ||
Rectum | 160 | 95.2 | |||
Colon | 182 | 84.2 | |||
TNM stage | 0.000 | 2.70 (1.81–4.01) | 0.000 | ||
I-II | 195 | 120.7 | |||
III-IV | 147 | 64.6 | |||
Differentiation grade | 0.000 | 1.88(1.07–3.32) | 0.029 | ||
Well and Moderate | 312 | 96.6 | |||
Poorly | 30 | 61.8 | |||
Serosal invasion | 0.230 | ||||
Yes | 73 | 98.8 | |||
No | 269 | 92.3 | |||
MEK5 expression | 0.000 | 1.64 (1.09–2.47) | 0.017 | ||
Normal expression | 233 | 98.2 | |||
Over expression | 109 | 79.3 | |||