Table 2 Correlation between MEK5 expression and clinicopathologic characteristics
From: MEK5 overexpression is associated with the occurrence and development of colorectal cancer
MEK5 expression | ||||
|---|---|---|---|---|
All cases | Low (%) | High (%) | P value | |
Sex | 0.648 | |||
Female | 157 | 105(66.9) | 52(33.1) | |
Male | 185 | 128(69.2) | 57(30.8) | |
Age at diagnosis (years) | 0.697 | |||
< 60 | 159 | 110(69.2) | 49(30.8) | |
≥ 60 | 183 | 123(67.2) | 60(32.8) | |
Tumor location | 0.815 | |||
Rectum | 160 | 108(67.5) | 52(32.5) | |
Colon | 182 | 125(68.7) | 57(31.3) | |
pT (invasion depth) | 0.001 | |||
T1 | 5 | 5(100) | 0(0) | |
T2 | 57 | 50(87.7) | 7(12.3) | |
T3 | 242 | 157(64.9) | 85(35.1) | |
T4 | 38 | 21(55.3) | 17(44.7) | |
pN (lymph node metastasis) | 0.001 | |||
N0 | 205 | 155(75.6) | 50(24.4) | |
N1 | 87 | 47(54) | 40(46) | |
N2 | 50 | 31(62) | 19(38) | |
pM (distant metastasis) | 0.026 | |||
M0 | 312 | 218(69.9) | 94(30.1) | |
M1 | 30 | 15(50) | 15(50) | |
TNM stage | 0.000 | |||
I | 48 | 45(93.8) | 3(6.3) | |
II | 147 | 104(70.7) | 43(29.3) | |
III | 117 | 69(59) | 48(41) | |
IV | 30 | 15(50) | 15(50) | |
Differentiation grade | 0.002 | |||
Well | 28 | 25(89.3) | 3(10.7) | |
Moderate | 284 | 194(68.3) | 90(31.7) | |
Poorly | 30 | 14(46.7) | 16(53.3) | |
Pathology type | 0.812 | |||
Villous adenocarcinoma | 21 | 16(76.2) | 5(23.8) | |
Tubular adenocarcinoma | 277 | 187(67.5) | 90(32.5) | |
Mucinous adenocarcinoma | 29 | 19(65.5) | 10(34.5) | |
Others | 15 | 11(73.3) | 4(26.7) | |
Serosal invasion | 0.227 | |||
Yes | 73 | 54(74) | 19(26) | |
No | 269 | 179(66.5) | 90(33.5) | |