Table 1 AIF dependence is related to metabolic phenotype [53] and sensitivity to glycolytic inhibition in pancreatic cancer cells
From: Basal metabolic state governs AIF-dependent growth support in pancreatic cancer cells
Relative metabolic phenotype [53] | Sensitivity to glycolytic disruption | Sensitivity to AIF ablation | ||
|---|---|---|---|---|
Glycolysis/PPP | Fatty acid/ OXPHOS | |||
PANC-1 | Moderate | Moderate | Insensitive | Sensitive |
BxPC-3 | Moderate | Moderate | Insensitive | Sensitive |
HPAC | Low | High | Insensitive | Sensitive |
HPAF-II | High | Moderate | Moderately sensitive | Moderately sensitive |
MIA PaCa-2 | High | Low | Sensitive | Insensitive |