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Table 3 Plasma levels of estrone, estrone sulphate and SHBG among 325 never and past users of HRT, who were also current drinkers, as percentage difference in hormonal measurements per 10 g/day in alcohol intake

From: Alcohol-related breast cancer in postmenopausal women – effect of CYP19A1, PPARG and PPARGC1A polymorphisms on female sex-hormone levels and interaction with alcohol consumption and NSAID usage in a nested case-control study and a randomised controlled trial

Genotype

n (%)

Estrone

P-valueb

Estrone sulphate

P-valueb

SHBG

P-valueb

n = 325

∆ (95 % CI)a

∆ (95 % CI)a

∆ (95 % CI)a

rs10519297

       

AA

74 (23)

2 (−4;9)

 

3 (−3;9)

 

−5 (−11;0)

 

AG

182 (56)

3 (−1;6)

0.82

3 (0;7)

0.17

−6 (−9;-3)

0.23

GG

69 (21)

1 (−5;6)

 

4 (0;9)

 

−3 (−7;2)

 

AG + GG

251 (77)

2 (−1;5)

0.54

4 (1;6)

0.08

−5 (−8;-2)

0.27

rs749292

       

GG

98 (30)

3 (−2;7)

 

4 (1;8)

 

−5 (−8;-1)

 

AG

165 (51)

1 (−3;6)

0.96

3 (0;7)

0.38

−6 (−9;-2)

0.94

AA

62 (19)

2 (−5;10)

 

−1 (−7;6)

 

0 (−7;6)

 

AG + AA

227 (70)

1 (−2;5)

0.85

3 (−1;6)

0.15

−5 (−8;-1)

0.95

rs1062033

       

CC

86 (26)

1 (−3;6)

 

4 (0;8)

 

−5 (−9;-1)

 

CG

175 (54)

3 (−1;7)

0.76

4 (0;7)

0.11

−5 (−8;-2)

0.67

GG

64 (20)

1 (−6;8)

 

1 (−4;7)

 

−4 (−9;2)

 

CG + GG

239 (74)

2 (−1;6)

0.45

3 (0;7)

0.03

−5 (−8;-2)

0.90

rs10046

       

AA

85 (26)

3 (−3;10)

 

4 (−2;10)

 

−7 (−12;-1)

 

AG

173 (53)

2 (−1;7)

0.89

3 (0;7)

0.29

−6 (−9;-3)

0.06

GG

67 (21)

1 (−4;5)

 

3 (0;8)

 

−3 (−7;1)

 

AG + GG

240 (74)

2 (−1;5)

0.64

3 (1;6)

0.22

−5 (−7;-2)

0.24

rs4646

       

CC

177 (54)

3 (−2;7)

 

4 (0;7)

 

−4 (−8;-1)

 

CA

129 (40)

2 (−2;6)

0.49

3 (0;7)

0.30

−5 (−8;-2)

0.87

AA

19 (6)

−6 (−18;7)

 

6 (−5;19)

 

−8 (−18;4)

 

CA + AA

148 (46)

1 (−2;5)

0.41

3 (0;7)

0.14

−5 (−8;-2)

0.59

rs6493487

       

AA

192 (59)

3 (−1;8)

 

3 (−1;7)

 

−5 (−9;-1)

 

GA

125 (39)

2 (−2;5)

0.79

4 (1;8)

0.64

−5 (−8;-2)

0.60

GG

8 (2)

−1 (−11;11)

 

−1 (−10;9)

 

−5 (−14;5)

 

GA + GG

133 (41)

1 (−2;5)

0.79

4 (1;7)

0.97

−5 (−8;-2)

0.33

rs2008691

       

AA

210

2 (−2;6)

 

5 (2;8)

 

−6 (−9;-3)

 
 

(65)

      

GA

106 (32)

2 (−2;6)

0.67

1 (−2;5)

0.03

−4 (−8;0)

0.41

GG

9 (3)

12 (−4;31)

 

10 (−3;26)

 

6 (−7;22)

 

GA + GG

115 (35)

2 (−2;7)

0.70

2 (−2;6)

0.02

−4 (−7;0)

0.31

rs3751591

       

TT

232 (72)

2 (−1;6)

 

4 (1;7)

 

−5 (−8;-2)

 

TC

85 (26)

1 (−3;6)

0.78

2 (−2;6)

0.70

−5 (−8;-1)

0.90

CC

8 (2)

11 (−7;31)

 

9 (−6;26)

 

10 (−6;28)

 

CC vs. TT + TC

8 (2)

11 (−7;31)

0.81

9 (−6;26)

0.74

10 (−6;28)

0.86

rs2445762

       

TT

166 (51)

2 (−1;6)

 

3 (0;6)

 

−4 (−7;-1)

 

TC

139 (43)

1 (−3;6)

0.94

5 (1;9)

0.19

−6 (−10;-2)

0.72

CC

20 (6)

3 (−9;16)

 

−2 (−11;8)

 

−8 (−17;2)

 

TC + CC

159 (49)

1 (−3;6)

1.00

4 (0;8)

0.17

−6 (−10;-3)

0.61

rs11070844

       

CC

255 (78)

1 (−2;5)

 

3 (0;6)

 

−4 (−7;-1)

 

TC

66 (21)

5 (−1;11)

0.73

7 (1;12)

0.92

−7 (−12;-3)

0.06

TT

4 (1)

4 (−20;37)

 

15 (−9;45)

 

11 (−13;42)

 

TC + TT

70 (22)

5 (−1;11)

0.42

7 (2;12)

0.74

−7 (−12;-2)

0.03

  1. SHBG Sex-hormone binding globulin
  2. ΔPercentage difference in hormonal measurements per 10 g/day difference in alcohol intake
  3. aAdjusted for age, smoking (never, past, current) and BMI (kg/m2) at baseline
  4. bP-value for interaction. All interactions were kept in the models in all analyses even though there was no interaction
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BMC Cancer

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