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Table 4 Cumulative incidence and incidence rate of non-melanoma malignant skin lesions among patients with metastatic melanomaa

From: The occurrence of non-melanoma malignant skin lesions and non-cutaneous squamous-cell carcinoma among metastatic melanoma patients: an observational cohort study in Denmark

Outcome Event, n Cumulative Incidenceb (95 % CI) Incidence Rateb (95 % CI)
Among all patients (N = 2810 c , regardless of whether they had a history or pre-existing skin lesion)
CuSCC    
 Within 30 d after the index date 0 -- --
 Within 60 d after the index date 1 0.04 (0.004-0.2) 2.3 (0.3-16.2)
 Within 90 d after the index date 2 0.1 (0.02-0.2) 3.1 (0.8-12.5)
 Within 180 d after the index date 2 0.1 (0.02-0.2) 1.7 (0.4-6.7)
 Within 270 d after the index date 4 0.1 (0.05-0.3) 2.4 (0.9-6.4)
 Within 365 d after the index date 7 0.2 (0.1-0.5) 3.3 (1.6-7.0)
 Ever post index date 26 0.9 (0.6-1.3) 3.7 (2.5-5.4)
BCC    
 Within 30 d after the index date 15 0.5 (0.3-0.9) 66.7 (40.2-110.6)
 Within 60 d after the index date 26 0.9 (0.6-1.3) 59.6 (40.5-87.5)
 Within 90 d after the index date 30 1.1 (0.7-1.5) 47.1 (33.0-67.4)
 Within 180 d after the index date 50 1.8 (1.3-2.3) 42.5 (32.2-56.1)
 Within 270 d after the index date 59 2.1 (1.6 - 2.7) 36.0 (27.9- 46.4)
 Within 365 d after the index date 68 2.4 (1.9 - 3.0) 32.9 (25.9- 41.7)
 Ever post index date 140 5.0 (4.2 - 5.8) 21.0 (17.8- 24.8)
Bowen’s disease    
 Within 30 d after the index date 0 -- --
 Within 60 d after the index date 0 -- --
 Within 90 d after the index date 0 -- --
 Within 180 d after the index date 1 0.04 (0.004-0.2) 0.8 (0.1-6.0)
 Within 270 d after the index date 3 0.1 (0.03-0.3) 1.8 (0.6-5.6)
 Within 365 d after the index date 3 0.1 (0.03-0.3) 1.4 (0.5-4.4)
 Ever post index date 9 0.3 (0.2-0.6) 1.3 (0.7-2.4)
KA    
 Within 30 d after the index date 0 -- --
 Within 60 d after the index date 0 -- --
 Within 90 d after the index date 0 -- --
 Within 180 d after the index date 0 -- --
 Within 270 d after the index date 1 0.04 (0.004-0.2) 0.6 (0.1-4.3)
 Within 365 d after the index date 3 0.1 (0.03-0.3) 1.4 (0.5-4.4)
 Ever post index date 10 0.4 (0.2-0.6) 1.4 (0.8-2.6)
AK    
 Within 30 d after the index date 7 0.2 (0.1-0.5) 31.1 (14.8-65.2)
 Within 60 d after the index date 13 0.5 (0.3-0.8) 29.7 (17.2-51.1)
 Within 90 d after the index date 17 0.6 (0.4-0.9) 26.6 (16.5-42.8)
 Within 180 d after the index date 22 0.8 (0.5-1.2) 18.6 (12.2-28.2)
 Within 270 d after the index date 33 1.2 (0.8-1.6) 20.0 (14.2-28.1)
 Within 365 d after the index date 41 1.5 (1.1-2.0) 19.6 (14.4-26.6)
 Ever post index date 91 3.2 (2.6-3.9) 13.3 (10.8-16.3)
Among patients who had no history or pre-existing skin lesion (N = 2496)
cuSCC    
 Within 30 d after the index date 0 -- --
 Within 60 d after the index date 0 -- --
 Within 90 d after the index date 0 -- --
 Within 180 d after the index date 0 -- --
 Within 270 d after the index date 1 0.04 (0.004-0.2) 0.7 (0.1-4.8)
 Within 365 d after the index date 3 0.1 (0.03-0.3) 1.6 (0.5-4.9)
 Ever post index date 17 0.7 (0.4-1.1) 2.7 (1.7-4.3)
BCC    
 Within 30 d after the index date 10 0.4 (0.2-0.7) 49.9 (26.9-92.8)
 Within 60 d after the index date 14 0.6 (0.3-0.9) 36.0 (21.3-60.7)
 Within 90 d after the index date 15 0.6 (0.4-1.0) 26.4 (15.9-43.8)
 Within 180 d after the index date 24 1.0 (0.6-1.4) 22.8 (15.3-34.0)
 Within 270 d after the index date 27 1.1 (0.7-1.5) 18.3 (12.6-26.7)
 Within 365 d after the index date 30 1.2 (0.8-1.7) 16.1 (11.3-23.1)
 Ever post index date 77 3.1 (2.5-3.8) 12.5 (10.0-15.7)
Bowen’s disease    
 Within 30 d after the index date 0 -- --
 Within 60 d after the index date 0 -- --
 Within 90 d after the index date 0 -- --
 Within 180 d after the index date 1 0.04 (0.004-0.2) 0.9 (0.1-6.7)
 Within 270 d after the index date 1 0.04 (0.004-0.2) 0.7 (0.01-4.8)
 Within 365 d after the index date 1 0.04 (0.004-0.2) 0.5 (0.1-3.8)
 Ever post index date 5 0.2 (0.1-0.4) 0.8 (0.3-1.9)
KA    
 Within 30 d after the index date 0 -- --
 Within 60 d after the index date 0 -- --
 Within 90 d after the index date 0 -- --
 Within 180 d after the index date 0 -- --
 Within 270 d after the index date 0 -- --
 Within 365 d after the index date 1 0.04 (0.004-0.2) 0.5 (0.1-3.8)
 Ever post index date 6 0.2 (0.1-0.5) 0.9 (0.4-2.1)
AK    
 Within 30 d after the index date 4 0.2 (0.1-0.4) 19.9 (7.5-53.2)
 Within 60 d after the index date 8 0.3 (0.2-0.6) 20.5 (10.3-41.0)
 Within 90 d after the index date 10 0.4 (0.2-0.7) 17.6 (9.5-32.6)
 Within 180 d after the index date 13 0.5 (0.3-0.9) 12.3 (7.2- 21.2)
 Within 270 d after the index date 19 0.8 (0.5-1.2) 12.9 (8.2-20.2)
 Within 365 d after the index date 23 0.9 (0.6-1.4) 12.3 (8.2-18.5)
 Ever post index date 53 2.1 (1.6-2.7) 8.5 (6.5-11.1)
  1. aAbbreviation: BCC, basal cell carcinoma; cuSCC, cutaneous squamous cell carcinoma; AK, actinic keratosis; and KA, keratoacanthoma
  2. bThe incidence analysis was conducted among 2810 patients, because 4 patients died on the index date and were excluded
  3. cCumulative incidence, %; incidence rate, per 1000 person-years