Table 4 Cumulative incidence and incidence rate of non-melanoma malignant skin lesions among patients with metastatic melanomaa
Outcome | Event, n | Cumulative Incidenceb (95 % CI) | Incidence Rateb (95 % CI) |
|---|---|---|---|
Among all patients (N = 2810 c , regardless of whether they had a history or pre-existing skin lesion) | |||
CuSCC | |||
Within 30 d after the index date | 0 | -- | -- |
Within 60 d after the index date | 1 | 0.04 (0.004-0.2) | 2.3 (0.3-16.2) |
Within 90 d after the index date | 2 | 0.1 (0.02-0.2) | 3.1 (0.8-12.5) |
Within 180 d after the index date | 2 | 0.1 (0.02-0.2) | 1.7 (0.4-6.7) |
Within 270 d after the index date | 4 | 0.1 (0.05-0.3) | 2.4 (0.9-6.4) |
Within 365 d after the index date | 7 | 0.2 (0.1-0.5) | 3.3 (1.6-7.0) |
Ever post index date | 26 | 0.9 (0.6-1.3) | 3.7 (2.5-5.4) |
BCC | |||
Within 30 d after the index date | 15 | 0.5 (0.3-0.9) | 66.7 (40.2-110.6) |
Within 60 d after the index date | 26 | 0.9 (0.6-1.3) | 59.6 (40.5-87.5) |
Within 90 d after the index date | 30 | 1.1 (0.7-1.5) | 47.1 (33.0-67.4) |
Within 180 d after the index date | 50 | 1.8 (1.3-2.3) | 42.5 (32.2-56.1) |
Within 270 d after the index date | 59 | 2.1 (1.6 - 2.7) | 36.0 (27.9- 46.4) |
Within 365 d after the index date | 68 | 2.4 (1.9 - 3.0) | 32.9 (25.9- 41.7) |
Ever post index date | 140 | 5.0 (4.2 - 5.8) | 21.0 (17.8- 24.8) |
Bowen’s disease | |||
Within 30 d after the index date | 0 | -- | -- |
Within 60 d after the index date | 0 | -- | -- |
Within 90 d after the index date | 0 | -- | -- |
Within 180 d after the index date | 1 | 0.04 (0.004-0.2) | 0.8 (0.1-6.0) |
Within 270 d after the index date | 3 | 0.1 (0.03-0.3) | 1.8 (0.6-5.6) |
Within 365 d after the index date | 3 | 0.1 (0.03-0.3) | 1.4 (0.5-4.4) |
Ever post index date | 9 | 0.3 (0.2-0.6) | 1.3 (0.7-2.4) |
KA | |||
Within 30 d after the index date | 0 | -- | -- |
Within 60 d after the index date | 0 | -- | -- |
Within 90 d after the index date | 0 | -- | -- |
Within 180 d after the index date | 0 | -- | -- |
Within 270 d after the index date | 1 | 0.04 (0.004-0.2) | 0.6 (0.1-4.3) |
Within 365 d after the index date | 3 | 0.1 (0.03-0.3) | 1.4 (0.5-4.4) |
Ever post index date | 10 | 0.4 (0.2-0.6) | 1.4 (0.8-2.6) |
AK | |||
Within 30 d after the index date | 7 | 0.2 (0.1-0.5) | 31.1 (14.8-65.2) |
Within 60 d after the index date | 13 | 0.5 (0.3-0.8) | 29.7 (17.2-51.1) |
Within 90 d after the index date | 17 | 0.6 (0.4-0.9) | 26.6 (16.5-42.8) |
Within 180 d after the index date | 22 | 0.8 (0.5-1.2) | 18.6 (12.2-28.2) |
Within 270 d after the index date | 33 | 1.2 (0.8-1.6) | 20.0 (14.2-28.1) |
Within 365 d after the index date | 41 | 1.5 (1.1-2.0) | 19.6 (14.4-26.6) |
Ever post index date | 91 | 3.2 (2.6-3.9) | 13.3 (10.8-16.3) |
Among patients who had no history or pre-existing skin lesion (N = 2496) | |||
cuSCC | |||
Within 30 d after the index date | 0 | -- | -- |
Within 60 d after the index date | 0 | -- | -- |
Within 90 d after the index date | 0 | -- | -- |
Within 180 d after the index date | 0 | -- | -- |
Within 270 d after the index date | 1 | 0.04 (0.004-0.2) | 0.7 (0.1-4.8) |
Within 365 d after the index date | 3 | 0.1 (0.03-0.3) | 1.6 (0.5-4.9) |
Ever post index date | 17 | 0.7 (0.4-1.1) | 2.7 (1.7-4.3) |
BCC | |||
Within 30 d after the index date | 10 | 0.4 (0.2-0.7) | 49.9 (26.9-92.8) |
Within 60 d after the index date | 14 | 0.6 (0.3-0.9) | 36.0 (21.3-60.7) |
Within 90 d after the index date | 15 | 0.6 (0.4-1.0) | 26.4 (15.9-43.8) |
Within 180 d after the index date | 24 | 1.0 (0.6-1.4) | 22.8 (15.3-34.0) |
Within 270 d after the index date | 27 | 1.1 (0.7-1.5) | 18.3 (12.6-26.7) |
Within 365 d after the index date | 30 | 1.2 (0.8-1.7) | 16.1 (11.3-23.1) |
Ever post index date | 77 | 3.1 (2.5-3.8) | 12.5 (10.0-15.7) |
Bowen’s disease | |||
Within 30 d after the index date | 0 | -- | -- |
Within 60 d after the index date | 0 | -- | -- |
Within 90 d after the index date | 0 | -- | -- |
Within 180 d after the index date | 1 | 0.04 (0.004-0.2) | 0.9 (0.1-6.7) |
Within 270 d after the index date | 1 | 0.04 (0.004-0.2) | 0.7 (0.01-4.8) |
Within 365 d after the index date | 1 | 0.04 (0.004-0.2) | 0.5 (0.1-3.8) |
Ever post index date | 5 | 0.2 (0.1-0.4) | 0.8 (0.3-1.9) |
KA | |||
Within 30 d after the index date | 0 | -- | -- |
Within 60 d after the index date | 0 | -- | -- |
Within 90 d after the index date | 0 | -- | -- |
Within 180 d after the index date | 0 | -- | -- |
Within 270 d after the index date | 0 | -- | -- |
Within 365 d after the index date | 1 | 0.04 (0.004-0.2) | 0.5 (0.1-3.8) |
Ever post index date | 6 | 0.2 (0.1-0.5) | 0.9 (0.4-2.1) |
AK | |||
Within 30 d after the index date | 4 | 0.2 (0.1-0.4) | 19.9 (7.5-53.2) |
Within 60 d after the index date | 8 | 0.3 (0.2-0.6) | 20.5 (10.3-41.0) |
Within 90 d after the index date | 10 | 0.4 (0.2-0.7) | 17.6 (9.5-32.6) |
Within 180 d after the index date | 13 | 0.5 (0.3-0.9) | 12.3 (7.2- 21.2) |
Within 270 d after the index date | 19 | 0.8 (0.5-1.2) | 12.9 (8.2-20.2) |
Within 365 d after the index date | 23 | 0.9 (0.6-1.4) | 12.3 (8.2-18.5) |
Ever post index date | 53 | 2.1 (1.6-2.7) | 8.5 (6.5-11.1) |