The occurrence of non-melanoma malignant skin lesions and non-cutaneous squamous-cell carcinoma among metastatic melanoma patients: an observational cohort study in Denmark

Table 2 Characteristics for eligible metastatic melanoma patients who had no history of cancer^a

	Overall		Stage IV at initial diagnosis		Progressed to stage IV
	N	%	N	%	N	%
Total N	2814	100.0	1313	100.0	1501	100.0
Year at diagnosis^b
1997-2000	596	21.2	386	64.8	210	35.2
2001-2005	1015	36.1	438	43.2	577	56.8
2006-2010	1203	42.8	489	40.6	714	59.4
Age (y) at diagnosis
Mean (SD)	62.8 (15.4)		63.2 (14.9)		62.4 (15.9)
Median (range)	64 (19–103)		64 (21–97)		63 (19–103)
18- < 40 yrs	240	8.5	101	7.7	139	9.3
40- < 55 yrs	561	19.9	249	19.0	312	20.8
55- < 65 yrs	669	23.8	327	24.9	342	22.8
65- < 75 yrs	629	22.4	292	22.2	337	22.5
75- < 85 yrs	536	19.0	270	20.6	266	17.7
85+ yrs	179	6.4	74	5.6	105	7.0
Male^b	1540	54.7	679	51.7	861	57.4
Born in Denmark	2727	96.9	1269	96.6	1458	97.1
Site of metastasis^b
Skin	1527	54.3	515	39.2	1012	67.4
Soft tissue	166	5.9	69	5.3	97	6.5
Liver	115	4.1	47	3.6	68	4.5
Lung	89	3.2	37	2.8	52	3.5
GI Tract	64	2.3	33	2.5	31	2.1
Brain	59	2.1	21	1.6	38	2.5
Bone	39	1.4	19	1.4	20	1.3
Salivary gland	34	1.2	10	0.8	24	1.6
Mamma	28	1.0	15	1.1	13	0.9
Cytology, pleura	17	0.6	8	0.6	9	0.6
Gallbladder/Pancreas	5	0.2	3	0.2	2	0.1
Vulva	5	0.2	3	0.2	2	0.1
Mucous membrane	6	0.2	4	0.3	2	0.1
Unspecified or unknown	660	23.5	529	40.3	131	8.7
Death^b	2093	74.4	1003	76.4	1090	72.6
Time (mo) to death^b, median (range)	9.7 (0–176)		8.6 (0–176)		10.6 (0–160)
Mortality rates (95 % CI), per 1000 person-years	289.2 (277.1 – 301.9)		303.2 (285.0 – 322.5)		277.5 (261.5 – 294.4)

^aPatients were excluded if they had a history of cancer, other than melanoma, basal cell carcinoma, cutaneous squamous cell carcinoma, Bowen’s disease, actinic keratosis and keratoacanthoma, before the metastatic melanoma diagnosis
^bChi squared test P value: year at diagnosis (<0.0001), gender (0.003), site of metastasis (<0.0001) and number of death (0.02); Wilcoxon rank sum test P-value: time to death (<0.05)

ISSN: 1471-2407