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Table 2 Characteristics for eligible metastatic melanoma patients who had no history of cancera

From: The occurrence of non-melanoma malignant skin lesions and non-cutaneous squamous-cell carcinoma among metastatic melanoma patients: an observational cohort study in Denmark

  Overall Stage IV at initial diagnosis Progressed to stage IV
  N % N % N %
Total N 2814 100.0 1313 100.0 1501 100.0
Year at diagnosisb       
 1997-2000 596 21.2 386 64.8 210 35.2
 2001-2005 1015 36.1 438 43.2 577 56.8
 2006-2010 1203 42.8 489 40.6 714 59.4
Age (y) at diagnosis    
 Mean (SD) 62.8 (15.4) 63.2 (14.9) 62.4 (15.9)
 Median (range) 64 (19–103) 64 (21–97) 63 (19–103)
 18- < 40 yrs 240 8.5 101 7.7 139 9.3
 40- < 55 yrs 561 19.9 249 19.0 312 20.8
 55- < 65 yrs 669 23.8 327 24.9 342 22.8
 65- < 75 yrs 629 22.4 292 22.2 337 22.5
 75- < 85 yrs 536 19.0 270 20.6 266 17.7
 85+ yrs 179 6.4 74 5.6 105 7.0
Maleb 1540 54.7 679 51.7 861 57.4
Born in Denmark 2727 96.9 1269 96.6 1458 97.1
Site of metastasisb       
 Skin 1527 54.3 515 39.2 1012 67.4
 Soft tissue 166 5.9 69 5.3 97 6.5
 Liver 115 4.1 47 3.6 68 4.5
 Lung 89 3.2 37 2.8 52 3.5
 GI Tract 64 2.3 33 2.5 31 2.1
 Brain 59 2.1 21 1.6 38 2.5
 Bone 39 1.4 19 1.4 20 1.3
 Salivary gland 34 1.2 10 0.8 24 1.6
 Mamma 28 1.0 15 1.1 13 0.9
 Cytology, pleura 17 0.6 8 0.6 9 0.6
 Gallbladder/Pancreas 5 0.2 3 0.2 2 0.1
 Vulva 5 0.2 3 0.2 2 0.1
 Mucous membrane 6 0.2 4 0.3 2 0.1
 Unspecified or unknown 660 23.5 529 40.3 131 8.7
Deathb 2093 74.4 1003 76.4 1090 72.6
 Time (mo) to deathb, median (range) 9.7 (0–176) 8.6 (0–176) 10.6 (0–160)
Mortality rates (95 % CI), per 1000 person-years 289.2
(277.1 – 301.9)
303.2
(285.0 – 322.5)
277.5
(261.5 – 294.4)
  1. aPatients were excluded if they had a history of cancer, other than melanoma, basal cell carcinoma, cutaneous squamous cell carcinoma, Bowen’s disease, actinic keratosis and keratoacanthoma, before the metastatic melanoma diagnosis
  2. bChi squared test P value: year at diagnosis (<0.0001), gender (0.003), site of metastasis (<0.0001) and number of death (0.02); Wilcoxon rank sum test P-value: time to death (<0.05)