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Table 1 IC50 values of KC-53 in vitro antiproliferative activity in human cell lines

From: Selective activation of TNFR1 and NF-κB inhibition by a novel biyouyanagin analogue promotes apoptosis in acute leukemia cells

Cell Line

IC50 (μΜ)

HL-60

2.3 ± 1.0

CCRF/CEM

2.4 ± 1.0

LoVo

2.5 ± 1.6

Jurkat

3.4 ± 1.7

Daudi

3.8 ± 1.9

KHOS

5.0 ± 2.0

MDA-MB-231-TXSA

8.0 ± 3.5

STSA

15.4 ± 5.2

MCF-12 F

15.5 ± 5.5

MCF-7

16.0 ± 3.5

Raji

16.3 ± 6.1

A549

19.1 ± 10

Ishikawa

21.1 ± 10

PC-3

33.6 ± 9.7

PBMCs

>60

  1. Cells were incubated with increasing concentrations of KC-53 (0–60 μΜ) for 48 h. The IC50 values were calculated from MTT viability curves. The data are expressed as the mean ± SD of three independent experiments performed in triplicate
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BMC Cancer

ISSN: 1471-2407

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