Table 3 Summary of subgroup analysis by localization of survivin expression

NSCLC vs. Control

All

19

7.16(4.63-11.07)

<0.001

58.1 %

0.001

Cytoplasma

9

7.14(4.19-12.16)

<0.001

43.8 %

0.076

Cytoplasma or nuclearus

5

3.96(1.93-8.14)

<0.001

46.1 %

0.115

Cytoplasma and nuclearus

2

17.41(1.2-252.4)

0.036

70.5 %

0.065

Squamous cell carcinoma vs. Adenocarcinoma

All

22

0.99(0.92, 1.07)

0.866

7.0 %

0.367

Cytoplasma

11

0.98(0.88-1.08)

0.641

0 %

0.767

Cytoplasma or nuclearus

6

0.98(0.83-1.15)

0.771

30.8 %

0.204

Cytoplasma and nuclearus

2

1.74(1.12-2.71)

0.013

0 %

0.324

Well/Moderately differentiated vs. Poor differentiated

All

21

0.80(0.73-0.87)

<0.001

45.4 %

0.013

Cytoplasma

8

0.84(0.75-0.93)

0.001

19.6 %

0.274

Cytoplasma or nuclearus

7

0.68(0.52-0.88)

0.003

68.9 %

0.004

Cytoplasma and nuclearus

2

0.73(0.46-1.16)

0.179

42.7 %

0.186

TNMI/II stage vs. TNM III/IVstage

All

26

0.75(0.67-0.84)

<0.001

72.7 %

<0.001

Cytoplasma

12

0.83(0.69-1.01)

0.059

74.1 %

<0.001

Cytoplasma or nuclearus

8

0.73(0.61-0.88)

0.001

74.5 %

<0.001

Cytoplasma and nuclearus

2

0.73(0.41-1.29)

0.278

59.7 %

0.115

Lymph node metastasis vs. Non lymph node metastasis

All

25

1.14(1.01-1.29)

0.035

71.5 %

<0.001

Cytoplasma

10

1.24(1.07-1.44)

0.005

53.1 %

0.024

Cytoplasma or nuclearus

9

1.12(0.89-1.41)

0.352

76.6 %

<0.001

Cytoplasma and nuclearus

2

0.96(0.32-2.91)

0.949

83.1 %

0.015

Small Tumor vs. Big Tumor

All

11

0.95(0.86-1.05)

0.336

18.1 %

0.272

Cytoplasma

6

0.97(0.79-1.19)

0.738

48.3 %

0.085

Cytoplasma or nuclearus

4

0.92(0.83-1.04)

0.226

0 %

0.565

Cytoplasma and nuclearus

1

1.09(0.71-1.67)

0.691

/

/