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Table 3 Summary of subgroup analysis by localization of survivin expression

From: Survivin protein expression is involved in the progression of non-small cell lung cancer in Asians: a meta-analysis

Contrasts Subcellular locolization Study (n) Combined RR (95 % CI) P(Z) I2 P(Q)
NSCLC vs. Control All 19 7.16(4.63-11.07) <0.001 58.1 % 0.001
  Cytoplasma 9 7.14(4.19-12.16) <0.001 43.8 % 0.076
  Cytoplasma or nuclearus 5 3.96(1.93-8.14) <0.001 46.1 % 0.115
  Cytoplasma and nuclearus 2 17.41(1.2-252.4) 0.036 70.5 % 0.065
Squamous cell carcinoma vs. Adenocarcinoma All 22 0.99(0.92, 1.07) 0.866 7.0 % 0.367
  Cytoplasma 11 0.98(0.88-1.08) 0.641 0 % 0.767
  Cytoplasma or nuclearus 6 0.98(0.83-1.15) 0.771 30.8 % 0.204
  Cytoplasma and nuclearus 2 1.74(1.12-2.71) 0.013 0 % 0.324
Well/Moderately differentiated vs. Poor differentiated All 21 0.80(0.73-0.87) <0.001 45.4 % 0.013
  Cytoplasma 8 0.84(0.75-0.93) 0.001 19.6 % 0.274
  Cytoplasma or nuclearus 7 0.68(0.52-0.88) 0.003 68.9 % 0.004
  Cytoplasma and nuclearus 2 0.73(0.46-1.16) 0.179 42.7 % 0.186
TNMI/II stage vs. TNM III/IVstage All 26 0.75(0.67-0.84) <0.001 72.7 % <0.001
  Cytoplasma 12 0.83(0.69-1.01) 0.059 74.1 % <0.001
  Cytoplasma or nuclearus 8 0.73(0.61-0.88) 0.001 74.5 % <0.001
  Cytoplasma and nuclearus 2 0.73(0.41-1.29) 0.278 59.7 % 0.115
Lymph node metastasis vs. Non lymph node metastasis All 25 1.14(1.01-1.29) 0.035 71.5 % <0.001
  Cytoplasma 10 1.24(1.07-1.44) 0.005 53.1 % 0.024
  Cytoplasma or nuclearus 9 1.12(0.89-1.41) 0.352 76.6 % <0.001
  Cytoplasma and nuclearus 2 0.96(0.32-2.91) 0.949 83.1 % 0.015
Small Tumor vs. Big Tumor All 11 0.95(0.86-1.05) 0.336 18.1 % 0.272
  Cytoplasma 6 0.97(0.79-1.19) 0.738 48.3 % 0.085
  Cytoplasma or nuclearus 4 0.92(0.83-1.04) 0.226 0 % 0.565
  Cytoplasma and nuclearus 1 1.09(0.71-1.67) 0.691 / /