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Table 4 Staining patterns of each immunohistochemical marker in sample groups of non-progressor or with progressors and sporadic colorectal neoplasia

From: Comparative analysis of copy number variations in ulcerative colitis associated and sporadic colorectal neoplasia

Genes

UC-NP n = 20

UC-P n = 18

S-CRN n = 14

1 p-value

2 p-value

3 p-value

p53 +

7 (35 %)

16 (89 %)

9 (64 %)

0.0009

0.1

0.1

<50 %

2 (28.6 %)

1 (6.2 %)

1 (11.1 %)

>50 %

5 (71.4 %)

15 (93.8 %)

8 (89 %)

CCND1 +

12 (60 %)

17 (94 %)

14 (100 %)

0.02

0.01

NS

<25 %

9 (75 %)

5 (29.4 %)

–

>25 %

3 (25 %)

12 (70.6 %)

14 (100 %)

AMACR +

–

9 (50 %)

6 (43 %)

–

–

–

<5 %

–

2 (22.2 %)

–

>5 %

–

7 (77.8 %)

6 (100 %)

EGFR +

–

10 (56 %)

7 (50 %)

–

–

–

<5 %

–

2 (20 %)

1 (14.3 %)

>5 %

–

8 (80 %)

6 (85.7 %)

C-MYC +

4 (20 %)

10 (56 %)

7 (50 %)

0.04

0.1

NS

<5 %

2 (50 %)

1 (10 %)

2 (28.6 %)

>5 %

2 (50 %)

9 (90 %)

5 (71.4 %)

ERBB2 +

2 (10 %)

4 (22 %)

6 (43 %)

NS

0.04

NS

<5 %

2 (100 %)

–

2 (33.3 %)

>5 %

–

4 (100 %)

4 (66.7 %)

FNDC3A +

11 (55 %)

16 (88.9 %)

14 (100 %)

0.032

0.004

NS

  1. The number and percentage of patients with a positive immunostaining according to staining intensity and the percentage of stained cells in these patients.1 p-value: statistical comparison between UC-NP vs UC-P; 2 p-value: statistical comparison between UC-NP vs S-CRN; 3 p-value: statistical comparison between UC-P vs S-CRN