Table 1 Subject- and disease-related variables
From: Prognostic impact of IKZF1 deletion in adults with common B-cell acute lymphoblastic leukemia
Variable | All subjects | IKZF1-deleted | IKZF1 wild type | P-value |
|---|---|---|---|---|
N | 146 | 68 (47Â %) | 78 (53Â %) | Â |
Age, y | ||||
 Median (range) | 27 (14–70) | 34 (15–70) | 22 (14–59) | 0.045 |
Gender | ||||
 Male | 72 | 33 (46 %) | 39 (54 %) | 0.859 |
WBC (×10E + 9/L) | ||||
 Median (range) | 10 (0.5-435) | 14 (2–435) | 9 (0.5-168) | 0.008 |
Hemoglobin (g/L) | ||||
 Median (range) | 90 (23–157) | 92 (35–148) | 89 (23–157) | 0.300 |
Platelets (×10E + 9/L) | ||||
 Median (range) | 57 (0.2–313) | 58 (0.2–311) | 52 (2–313) | 0.600 |
Bone marrow blasts, % | ||||
 Median (range) | 87 (28–99) | 86 (28–98) | 88 (28–99) | 0.300 |
  BCR-ABL1 | 52 | 39 (75 %)a | 13 (25 %)b | 0.000 |
Cytogenetics | ||||
 Normal | 47 | 19 (40 %) | 28 (60 %) | 0.305 |
 Abnormal | 81 | 38 (47 %) | 43 (53 %) |  |
  t(9;22) | 43 | 31 (72 %) | 12 (28 %) | 0.000 |
  t(X;2)(p22;p21) | 1 | 1 | 0 |  |
  del(9)(p13) | 1 | 1 | 0 |  |
  inv(9) | 2 | 1 | 1 |  |
  47,+X | 1 | 1 | 0 |  |
  Complex | 33 | 3 | 30 |  |
 Unknown | 18 | 11 (61 %) | 7 (39 %) |  |