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Table 4 Univariate and multivariate analyses of CTSB and CTSD for prognosis of patients with nasopharyngeal carcinoma

From: Diagnostic values of serum cathepsin B and D in patients with nasopharyngeal carcinoma

Variables Number Median PFS Univariate analysis Multivariate analysis
   (months) p value p value RR
CTSB
  > 12.4 mg/l 42 37.0 0.699 0.878 0.938
  ≤ 12.4 mg/l 38 37.8    
CTSD
  > 14.7 mg/l 39 35.9 0.216 0.341 1.524
  ≤ 14.7 mg/l 41 38.6    
Sex
 Men 54 37.2 0.902 0.566 1.286
 Women 26 35.8    
Age
  ≤ 45 years 40 37.3 0.699 0.779 0.892
  > 45 years 40 37.5    
TNM stage
 I + II 20 39.1 0.454 0.556 1.376
 III + IV 60 36.4    
VCA-IgA
  ≤ 1:160 45 37.5 0.735 0.769 1.265
  ≥ 1:320 35 36.8    
Smoking
 Yes 55 36.6 0.913 0.991 0.995
 No 25 37.9    
  1. Notes: CTSB cathepsin B, CTSD cathepsin D, PFS progression-free survival, RR relative risk, TNM tumor node metastasis, EBV Epstein-Barr virus, VCA-IgA viral capsid antigen-IgA