Diagnostic values of serum cathepsin B and D in patients with nasopharyngeal carcinoma

BMC Cancer

Table 4 Univariate and multivariate analyses of CTSB and CTSD for prognosis of patients with nasopharyngeal carcinoma

Variables	Number	Median PFS	Univariate analysis	Multivariate analysis
		(months)	p value	p value	RR
CTSB
> 12.4 mg/l	42	37.0	0.699	0.878	0.938
≤ 12.4 mg/l	38	37.8
CTSD
> 14.7 mg/l	39	35.9	0.216	0.341	1.524
≤ 14.7 mg/l	41	38.6
Sex
Men	54	37.2	0.902	0.566	1.286
Women	26	35.8
Age
≤ 45 years	40	37.3	0.699	0.779	0.892
> 45 years	40	37.5
TNM stage
I + II	20	39.1	0.454	0.556	1.376
III + IV	60	36.4
VCA-IgA
≤ 1:160	45	37.5	0.735	0.769	1.265
≥ 1:320	35	36.8
Smoking
Yes	55	36.6	0.913	0.991	0.995
No	25	37.9

Notes: CTSB cathepsin B, CTSD cathepsin D, PFS progression-free survival, RR relative risk, TNM tumor node metastasis, EBV Epstein-Barr virus, VCA-IgA viral capsid antigen-IgA

ISSN: 1471-2407