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Table 2 The down-regulated expression profiling of genes related to apoptosis in ACFP-treated human primary ovarian cancer cell in vitro

From: The milk-derived fusion peptide, ACFP, suppresses the growth of primary human ovarian cancer cells by regulating apoptotic gene expression and signaling pathways

Genebank ID

Gene symbol

Gene description

Ratio (ACFP/control)

Low dose

High dose

NM_000598

BCL-xl

bcl2-like 1

0.28

0.19

NM_000207

AKT1

v-akt murine thymoma viral oncogene homolog 1

0.29

0.27

NM_000995

CDC25C

cell division cycle 25C

0.29

0.32

NM_000891

CCNB1

cyclinB1

0.30

0.21

NM-022931

RAB18

RAB18, member RAS oncogene family

0.30

0.25

NM-084450

ZNF512

zinc finger protein 512

0.31

0.47

NM-060561

RINT-1

Rad50-interacting protein 1

0.32

0.17

NM-005429

POLH

polymerase (DNA directed), eta

0.33

0.12

NM-004638

MYLK

myosin, light polypeptide kinase

0.33

0.23

NM_063035

BCORL1

BCL6 co-repressor-like 1

0.35

0.25

NM-009448

MAP4K4

mitogen-activated protein kinase kinase kinase kinase 4

0.36

0.41

NM-051176

TCF/LEF1

lymphoid enhancer-binding factor 1

0.36

0.35

NM_005595

MAPK3/ERK1

mitogen-activated protein kinase 3

0.36

0.35

NM_003678

ITGA5

integrin, alpha 5 (fibronectin receptor, alpha polypeptide)

0.36

0.43

NM-005322

PLA2G5

phospholipase A2, group V

0.36

0.46

NM-084299

C17orf37

chromosome 17 open reading frame 37

0.39

0.38

NM-005682

PSMA1

proteasome (prosome, macropain) subunit, alpha type, 1

0.39

0.49

NM_023533

PIK3R5

phosphoinositide-3-kinase, regulatory subunit 5, p101

0.39

0.44

NM_002868

GRK4

G protein-coupled receptor kinase 4

0.42

0.37

NM-001544

CYP1A2

cytochrome P450, family 1, subfamily A, polypeptide 2

0.43

0.48

NM-003488

IGFBP5

insulin-like growth factor binding protein 5

0.45

0.23

NM-054984

PINX1

PIN2-interacting protein 1

0.45

0.47

NM-002970

GTF2IP1

general transcription factor IIi pseudogene 1

0.47

0.24

NM_002869

GRK5

G protein-coupled receptor kinase 5

0.47

0.47

NM_000573

BAG1

BCL2-associated athanogene

0.48

0.33

NM-007378

UPP1

uridine phosphorylase 1

0.48

0.42

NM_002870

GRK6

G protein-coupled receptor kinase 6

0.49

0.26

NM-008995

TNFSF18

tumor necrosis factor (ligand) superfamily, member 18

0.49

0.41

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BMC Cancer

ISSN: 1471-2407

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