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Table 1 The up-regulated expression profiling of genes related to apoptosis in ACFP-treated human primary ovarian cancer cells in vitro

From: The milk-derived fusion peptide, ACFP, suppresses the growth of primary human ovarian cancer cells by regulating apoptotic gene expression and signaling pathways

Genebank ID

Gene symbol

Gene description

Ratio (ACFP/control)

Low dose

High dose

NM_000581

BAX

BCL2-associated X protein

3.73

6.35

NM_000836

CASP3

caspase 3, apoptosis-related cysteine peptidase

3.72

5.34

NM_008106

PABPN1

poly(A) binding protein, nuclear 1

3.71

9.8

NM_001164

CKS2

CDC28 protein kinase regulatory subunit 2

3.67

8.95

NM_007920

BAT5

HLA-B associated transcript 5

3.66

7.48

NM_010653

SPINT2

serine protease inhibitor, Kunitz type, 2

3.58

10.25

NM_001855

DVL1

dishevelled segment polarity protein 1

3.58

2.46

NM_114904

C1QTNF6

C1q and tumor necrosis factor related protein 6

3.57

6.26

NM_002949

GSTM5

glutathione S-transferase M5

3.55

4.84

NM_007132

TNFRSF1A

tumor necrosis factor receptor superfamily, member 1A

3.50

2.15

NM_007132

TNFRSF1A

tumor necrosis factor receptor superfamily, member 1A

3.50

2.08

NM_055970

GNG12

guanine nucleotide binding protein (G protein), gamma 12

3.49

8.30

NM_009736

USP34

ubiquitin specific protease 34

3.49

4.52

NM_441241

LOC441241

similar to chaperonin containing TCP1, subunit 6A (zeta 1); chaperonin containing T-complex subunit 6

3.48

5.22

NM_114904

C1QTNF6

C1q and tumor necrosis factor related protein 6

3.43

6.26

NM_051275

FLJ39616

apoptosis-related protein PNAS-1

3.34

2.53

NM_009618

TRAF4

TNF receptor-associated factor 4

3.34

3.62

NM-016522

TMEFF1

transmembrane protein with EGF-like and two follistatin-like domains 1

3.33

7.91

NM_079829

FLJ13848

hypothetical protein FLJ13848

3.28

9.45

NM-009774

BTF/BCLAF1

BCL2-associated transcription factor 1

3.25

2.79

NM-006777

STAT5B

signal transducer and activator of transcription 5B

3.24

2.03

NM_001026

CDKN1A

cyclin-dependent kinase inhibitor 1A (p21, Cip1)

3.24

6.58

NM_001026

CDKN1A/p21

cyclin-dependent kinase inhibitor 1A (p21, Cip1)

3.24

3.58

NM_003665

IRF7

interferon regulatory factor 7

3.13

4.50

NM_081788

SNARK

likely ortholog of rat SNF1/AMP-activated protein kinase

3.08

3.11

NM_000390

ARHE

ras homolog gene family, member E

2.99

3.39

NM_005696

PSMB8

proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional protease 7)

2.97

3.24

NM_005603

MAPK13/p38 delta

mitogen-activated protein kinase 13

2.91

3.04

NM_010209

SUI1

putative translation initiation factor

2.89

9.85

NM-004824

NKX3-1

NK3 transcription factor related, locus 1 (Drosophila)

2.8

3.11

NM_005569

PKIA

protein kinase (cAMP-dependent, catalytic) inhibitor alpha

2.52

2.74

NM_009950

GOLGA5

golgi autoantigen, golgin subfamily a, 5

2.46

2.95

NM_079370

BCL2L14

BCL2-like 14 (apoptosis facilitator)

2.44

2.57

NM_008795

TNFRSF10B

tumor necrosis factor receptor superfamily, member 10b

2.43

4.85

NM_029775

CARD10

caspase recruitment domain family, member 10

2.43

4.32

NM_002948

GSTM4

glutathione S-transferase M4

2.25

2.72

NM_079092

CARD14

caspase recruitment domain family, member 14

2.13

3.06

NM_007559

ZNF12

zinc finger protein 12 (KOX 3)

2.07

3.66

NM-006778

STAT6

signal transducer and activator of transcription 6, interleukin-4 induced

2.06

10.8

NM_000943

TNFRSF8

tumor necrosis factor receptor superfamily, member 8

2.05

3.22

NM_005599

MAPK8/JNK1

mitogen-activated protein kinase 8

2.04

2.74

NM_000943

TNFRSF8

tumor necrosis factor receptor superfamily, member 8

2.02

3.22

NM_000714

C1QG

complement component 1, q subcomponent, gamma polypeptide

2.02

2.68

NM_009262

STK17B

serine/threonine kinase 17b (apoptosis-inducing)

2.01

2.97

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BMC Cancer

ISSN: 1471-2407

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