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Table 1 The up-regulated expression profiling of genes related to apoptosis in ACFP-treated human primary ovarian cancer cells in vitro

From: The milk-derived fusion peptide, ACFP, suppresses the growth of primary human ovarian cancer cells by regulating apoptotic gene expression and signaling pathways

Genebank ID Gene symbol Gene description Ratio (ACFP/control)
Low dose High dose
NM_000581 BAX BCL2-associated X protein 3.73 6.35
NM_000836 CASP3 caspase 3, apoptosis-related cysteine peptidase 3.72 5.34
NM_008106 PABPN1 poly(A) binding protein, nuclear 1 3.71 9.8
NM_001164 CKS2 CDC28 protein kinase regulatory subunit 2 3.67 8.95
NM_007920 BAT5 HLA-B associated transcript 5 3.66 7.48
NM_010653 SPINT2 serine protease inhibitor, Kunitz type, 2 3.58 10.25
NM_001855 DVL1 dishevelled segment polarity protein 1 3.58 2.46
NM_114904 C1QTNF6 C1q and tumor necrosis factor related protein 6 3.57 6.26
NM_002949 GSTM5 glutathione S-transferase M5 3.55 4.84
NM_007132 TNFRSF1A tumor necrosis factor receptor superfamily, member 1A 3.50 2.15
NM_007132 TNFRSF1A tumor necrosis factor receptor superfamily, member 1A 3.50 2.08
NM_055970 GNG12 guanine nucleotide binding protein (G protein), gamma 12 3.49 8.30
NM_009736 USP34 ubiquitin specific protease 34 3.49 4.52
NM_441241 LOC441241 similar to chaperonin containing TCP1, subunit 6A (zeta 1); chaperonin containing T-complex subunit 6 3.48 5.22
NM_114904 C1QTNF6 C1q and tumor necrosis factor related protein 6 3.43 6.26
NM_051275 FLJ39616 apoptosis-related protein PNAS-1 3.34 2.53
NM_009618 TRAF4 TNF receptor-associated factor 4 3.34 3.62
NM-016522 TMEFF1 transmembrane protein with EGF-like and two follistatin-like domains 1 3.33 7.91
NM_079829 FLJ13848 hypothetical protein FLJ13848 3.28 9.45
NM-009774 BTF/BCLAF1 BCL2-associated transcription factor 1 3.25 2.79
NM-006777 STAT5B signal transducer and activator of transcription 5B 3.24 2.03
NM_001026 CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 3.24 6.58
NM_001026 CDKN1A/p21 cyclin-dependent kinase inhibitor 1A (p21, Cip1) 3.24 3.58
NM_003665 IRF7 interferon regulatory factor 7 3.13 4.50
NM_081788 SNARK likely ortholog of rat SNF1/AMP-activated protein kinase 3.08 3.11
NM_000390 ARHE ras homolog gene family, member E 2.99 3.39
NM_005696 PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional protease 7) 2.97 3.24
NM_005603 MAPK13/p38 delta mitogen-activated protein kinase 13 2.91 3.04
NM_010209 SUI1 putative translation initiation factor 2.89 9.85
NM-004824 NKX3-1 NK3 transcription factor related, locus 1 (Drosophila) 2.8 3.11
NM_005569 PKIA protein kinase (cAMP-dependent, catalytic) inhibitor alpha 2.52 2.74
NM_009950 GOLGA5 golgi autoantigen, golgin subfamily a, 5 2.46 2.95
NM_079370 BCL2L14 BCL2-like 14 (apoptosis facilitator) 2.44 2.57
NM_008795 TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 2.43 4.85
NM_029775 CARD10 caspase recruitment domain family, member 10 2.43 4.32
NM_002948 GSTM4 glutathione S-transferase M4 2.25 2.72
NM_079092 CARD14 caspase recruitment domain family, member 14 2.13 3.06
NM_007559 ZNF12 zinc finger protein 12 (KOX 3) 2.07 3.66
NM-006778 STAT6 signal transducer and activator of transcription 6, interleukin-4 induced 2.06 10.8
NM_000943 TNFRSF8 tumor necrosis factor receptor superfamily, member 8 2.05 3.22
NM_005599 MAPK8/JNK1 mitogen-activated protein kinase 8 2.04 2.74
NM_000943 TNFRSF8 tumor necrosis factor receptor superfamily, member 8 2.02 3.22
NM_000714 C1QG complement component 1, q subcomponent, gamma polypeptide 2.02 2.68
NM_009262 STK17B serine/threonine kinase 17b (apoptosis-inducing) 2.01 2.97